Effects of angiotensin-converting enzyme inhibitor and exercise training on exercise capacity and skeletal muscle

Naoyoshi Minami, Yingyu Li, Qi Guo, Takayuki Kawamura, Nobuyoshi Mori, Makoto Nagasaka, Mika Ogawa, Osamu Ito, Hajime Kurosawa, Masayuki Kanazawa, Masahiro Kohzuki

Research output: Contribution to journalArticlepeer-review

17 Citations (Scopus)

Abstract

OBJECTIVE: Physical fitness is closely related with cardiovascular health. We examined the effects of angiotensin-converting enzyme inhibitor, exercise training and their combination on exercise capacity as well as skeletal muscle fiber type and capillarity in spontaneously hypertensive rats (SHR). METHODS: Seven-week-old male SHR were allocated to four groups: sedentary control (C), treatment with perindopril (3 mg/kg per day) (Per), exercise training on a treadmill (EX), and their combination (Per + EX). Following 8-week interventions, rats were submitted to a stepwise exercise test on a treadmill. After experiments, fiber type and capillarity in soleus muscle were examined. RESULTS: Exercise capacity significantly increased in Per compared with in C. Combination of exercise training and perindopril further increased exercise capacity compared with perindopril alone, whereas there was no significant difference in exercise capacity between EX and Per + EX. Capillary density increased similarly in Per and EX compared with in C. Combination of exercise training and perindopril further increased capillary density compared with exercise training alone. The percentage of type I fiber increased only in Per + EX. CONCLUSIONS: We found that in growing SHR, chronic treatment with perindopril enhances untrained exercise capacity, while it does not affect acquired exercise capacity as a result of exercise training. We also found that perindopril promotes adaptive changes of skeletal muscle in response to exercise such as increases in capillary density and percentage of type I fiber.

Original languageEnglish
Pages (from-to)1241-1248
Number of pages8
JournalJournal of hypertension
Volume25
Issue number6
DOIs
Publication statusPublished - 2007 Jun

Keywords

  • Angiotensin-converting enzyme inhibitor
  • Capillary
  • Exercise capacity
  • Skeletal muscle fiber
  • Spontaneously hypertensive rats

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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