TY - JOUR
T1 - Effects of anesthetics on piperidine levels in mouse brain
AU - Miyata, Takeshi
AU - Okano, Yoshiro
AU - Fukunaga, Koji
AU - Takahama, Kazuo
AU - Hitoshi, Taizo
AU - Kasé, Yoshitoshi
N1 - Funding Information:
This work was supported by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science and Culture. We thank Messrs H. Morimoto and K. Iwasaki for their technical assistance.
PY - 1981/4/24
Y1 - 1981/4/24
N2 - Piperidine is one of the biogenic amines possessing potent pharmacological activity. Recent interest has focused on its possible role as an endogenous hypnogenic substance. Using a mass fragmentographic technique with deuterium-labelled piperidine as an internal standard, piperidine concentrations in brains of waking and deeply anesthetized mice were analyzed to compare piperidine levels in the brain under distinctly different states of consciousness. A rapid and significant increase in piperidine concentrations was found in the brain but not in blood of mice anesthetized with any one of pentobarbital, urethane, ether and halothane. The results, showing that CNS depression is accompanied by accumulation of piperidine in the brain, are consistent with the idea that piperidine may have a close connection with the mechanisms controlling the level of consciousness.
AB - Piperidine is one of the biogenic amines possessing potent pharmacological activity. Recent interest has focused on its possible role as an endogenous hypnogenic substance. Using a mass fragmentographic technique with deuterium-labelled piperidine as an internal standard, piperidine concentrations in brains of waking and deeply anesthetized mice were analyzed to compare piperidine levels in the brain under distinctly different states of consciousness. A rapid and significant increase in piperidine concentrations was found in the brain but not in blood of mice anesthetized with any one of pentobarbital, urethane, ether and halothane. The results, showing that CNS depression is accompanied by accumulation of piperidine in the brain, are consistent with the idea that piperidine may have a close connection with the mechanisms controlling the level of consciousness.
KW - Anesthesia
KW - Mass fragmentography
KW - Piperidine
KW - Sleep mechanism
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U2 - 10.1016/0014-2999(81)90388-5
DO - 10.1016/0014-2999(81)90388-5
M3 - Article
C2 - 7238588
AN - SCOPUS:0019431856
VL - 71
SP - 79
EP - 85
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
IS - 1
ER -