Effects of an ascorbic acid-derivative dentifrice in patients with gingivitis: A double-masked, randomized, controlled clinical trial

Yoshio Shimabukuro, Yohei Nakayama, Yorimasa Ogata, Kaoru Tamazawa, Hidetoshi Shimauchi, Tetsuya Nishida, Koichi Ito, Takashi Chikazawa, Shinsuke Kataoka, Shinya Murakami

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Background: Reactive oxygen species might be associated with the onset and progression of gingival inflammation. The aim of this study is to investigate the effect of a dentifrice containing L-ascorbic acid 2-phosphate magnesium salt (APM), a long-acting ascorbic acid derivative with antioxidant properties, on gingival inflammation. Methods: The clinical effects of APM were investigated in a multicenter, randomized, parallel-group, controlled clinical trial comprising 300 individuals with gingivitis. Half of the participants were given an APM-containing dentifrice and half were given a control dentifrice. The primary outcome was the gingival index (GI) at 3 months. Secondary outcomes included gingival redness as an indicator of the degree of local gingival inflammation, gingival bleeding as a measure of the gingivitis severity index, and total antioxidant activity of the saliva. Results: Under the intent-to-treat analysis, GI did not significantly differ between the groups (P = 0.12). However, under the per-protocol analysis, GI was significantly lower in the APM group (P = 0.01) than in the control group. In the APM group, gingival redness was significantly lower, and the difference from the baseline gingivitis severity index was significantly greater (P = 0.04 and P = 0.02, respectively). The total antioxidant activity of the saliva was significantly higher in the APM group (P = 0.03). The incidence of adverse events did not significantly differ between the groups (P >0.15). Conclusion: These findings indicate that the regular application of an APM-containing dentifrice could reduce gingival inflammation.

Original languageEnglish
Pages (from-to)27-35
Number of pages9
JournalJournal of periodontology
Volume86
Issue number1
DOIs
Publication statusPublished - 2015 Jan 1

Keywords

  • Antioxidants
  • Ascorbic acid
  • Controlled clinical trials
  • Dentifrices
  • Gingivitis
  • Randomized
  • Reactive oxygen species
  • Saliva

ASJC Scopus subject areas

  • Periodontics

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