Effects of adrenoceptor antagonists on the hyperthermia and hyperglycemia induced by prostaglandin F in rats

Katsunori Nonogaki, Akihisa Iguchi, Nobuo Sakamoto

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

We investigated the effects of intraperitoneal administration of adrenoceptor antagonists on the hyperthermia and hyperglycemia induced by prostaglandin F (50 μg) injected into the third cerebral ventricle in anesthetized rats. Phentolamine inhibited the hyperthermia and hyperglycemia induced by prostaglandin F. Prazosin inhibited the hyperthermia induced by prostaglandin F, while enhancing the hyperglycemia. Yohimbine inhibited the prostaglandin F-induced hyperglycemia without an effect on the hyperthermia. Propranolol had no effect on either prostaglandin F-induced hyperglycemia or hyperthermia. These observations suggest that the hyperglycemia induced by prostaglandin F is regulated by α2-adrenoceptor systems while the hyperthermia is regulated by α1-adrenoceptor systems in rats.

Original languageEnglish
Pages (from-to)177-180
Number of pages4
JournalEuropean Journal of Pharmacology
Volume262
Issue number1-2
DOIs
Publication statusPublished - 1994 Sep 1
Externally publishedYes

Keywords

  • Adrenoceptor
  • Hyperglycemia
  • Hyperthermia
  • Prostaglandin F

ASJC Scopus subject areas

  • Pharmacology

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