Effects of adrenoceptor antagonists on the hyperthermia and hyperglycemia induced by prostaglandin F2α in rats

Katsunori Nonogaki; Akihisa Iguchi; Nobuo Sakamoto

doi:10.1016/0014-2999(94)90043-4

Effects of adrenoceptor antagonists on the hyperthermia and hyperglycemia induced by prostaglandin F_2α in rats

Katsunori Nonogaki, Akihisa Iguchi, Nobuo Sakamoto

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

We investigated the effects of intraperitoneal administration of adrenoceptor antagonists on the hyperthermia and hyperglycemia induced by prostaglandin F_2α (50 μg) injected into the third cerebral ventricle in anesthetized rats. Phentolamine inhibited the hyperthermia and hyperglycemia induced by prostaglandin F_2α. Prazosin inhibited the hyperthermia induced by prostaglandin F_2α, while enhancing the hyperglycemia. Yohimbine inhibited the prostaglandin F_2α-induced hyperglycemia without an effect on the hyperthermia. Propranolol had no effect on either prostaglandin F_2α-induced hyperglycemia or hyperthermia. These observations suggest that the hyperglycemia induced by prostaglandin F_2α is regulated by α₂-adrenoceptor systems while the hyperthermia is regulated by α₁-adrenoceptor systems in rats.

Original language	English
Pages (from-to)	177-180
Number of pages	4
Journal	European Journal of Pharmacology
Volume	262
Issue number	1-2
DOIs	https://doi.org/10.1016/0014-2999(94)90043-4
Publication status	Published - 1994 Sep 1
Externally published	Yes

Keywords

Adrenoceptor
Hyperglycemia
Hyperthermia
Prostaglandin F

ASJC Scopus subject areas

Pharmacology

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10.1016/0014-2999(94)90043-4

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abstract = "We investigated the effects of intraperitoneal administration of adrenoceptor antagonists on the hyperthermia and hyperglycemia induced by prostaglandin F2α (50 μg) injected into the third cerebral ventricle in anesthetized rats. Phentolamine inhibited the hyperthermia and hyperglycemia induced by prostaglandin F2α. Prazosin inhibited the hyperthermia induced by prostaglandin F2α, while enhancing the hyperglycemia. Yohimbine inhibited the prostaglandin F2α-induced hyperglycemia without an effect on the hyperthermia. Propranolol had no effect on either prostaglandin F2α-induced hyperglycemia or hyperthermia. These observations suggest that the hyperglycemia induced by prostaglandin F2α is regulated by α2-adrenoceptor systems while the hyperthermia is regulated by α1-adrenoceptor systems in rats.",

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