We investigated the effects of intraperitoneal administration of adrenoceptor antagonists on the hyperthermia and hyperglycemia induced by prostaglandin F2α (50 μg) injected into the third cerebral ventricle in anesthetized rats. Phentolamine inhibited the hyperthermia and hyperglycemia induced by prostaglandin F2α. Prazosin inhibited the hyperthermia induced by prostaglandin F2α, while enhancing the hyperglycemia. Yohimbine inhibited the prostaglandin F2α-induced hyperglycemia without an effect on the hyperthermia. Propranolol had no effect on either prostaglandin F2α-induced hyperglycemia or hyperthermia. These observations suggest that the hyperglycemia induced by prostaglandin F2α is regulated by α2-adrenoceptor systems while the hyperthermia is regulated by α1-adrenoceptor systems in rats.
- Prostaglandin F
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