Effects of adrenergic neurotransmitter on K transport in superfused segments of rat submaxillary gland

K. Katoh, K. Kaneko, A. Nishiyama

    Research output: Contribution to journalArticle

    6 Citations (Scopus)

    Abstract

    The effect of the adrenergic neurotransmitter on K transport in the segments isolated from the rat submaxillary gland was investigated, employing the technique of electrical field stimulation (FS) and applying tyramine, a releasing drug for the catecholaminergic neurotansmitter. FS (16 Hz, 2 ms and 80 V for 1 min) caused a K release (peak value, 1.0 μmol/g/min) followed by a K uptake (peak value, 0.4 μmol/g/min) in the absence of any autonomic antagonist. Both FS-induced K release and uptake were blocked by the addition of tetrodotoxin (10-7 g/ml). In the presence of atropine (1.4×10-6 M), FS caused only a transient K uptake, which was abolished by the superimposed addition of propranolol (5×10-6 M). Application of tyramine (6×10-6-6×10-4 M) always only caused K uptake (peak value, 0.96 μmol/g/min), which was abolished by the addition of propranolol. The K uptake evoked either by FS or by tyramine application in the presence of atropine was not seen in the segments from rats pretreated (i.p.) with 6-hydroxydopamine. These results suggest that the adrenergic neurotransmitter activates mainly a β-adrenergic receptor and evokes K uptake through receptor activation.

    Original languageEnglish
    Pages (from-to)1-5
    Number of pages5
    JournalPflügers Archiv European Journal of Physiology
    Volume406
    Issue number1
    DOIs
    Publication statusPublished - 1986 Jan 1

    Keywords

    • Adrenergic neurotransmitter
    • Electrical field stimulation
    • K uptake
    • Submaxillary gland
    • Tyramine

    ASJC Scopus subject areas

    • Physiology
    • Clinical Biochemistry
    • Physiology (medical)

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