Abstract
The effect of the adrenergic neurotransmitter on K transport in the segments isolated from the rat submaxillary gland was investigated, employing the technique of electrical field stimulation (FS) and applying tyramine, a releasing drug for the catecholaminergic neurotansmitter. FS (16 Hz, 2 ms and 80 V for 1 min) caused a K release (peak value, 1.0 μmol/g/min) followed by a K uptake (peak value, 0.4 μmol/g/min) in the absence of any autonomic antagonist. Both FS-induced K release and uptake were blocked by the addition of tetrodotoxin (10-7 g/ml). In the presence of atropine (1.4×10-6 M), FS caused only a transient K uptake, which was abolished by the superimposed addition of propranolol (5×10-6 M). Application of tyramine (6×10-6-6×10-4 M) always only caused K uptake (peak value, 0.96 μmol/g/min), which was abolished by the addition of propranolol. The K uptake evoked either by FS or by tyramine application in the presence of atropine was not seen in the segments from rats pretreated (i.p.) with 6-hydroxydopamine. These results suggest that the adrenergic neurotransmitter activates mainly a β-adrenergic receptor and evokes K uptake through receptor activation.
Original language | English |
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Pages (from-to) | 1-5 |
Number of pages | 5 |
Journal | Pflügers Archiv European Journal of Physiology |
Volume | 406 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1986 Jan 1 |
Keywords
- Adrenergic neurotransmitter
- Electrical field stimulation
- K uptake
- Submaxillary gland
- Tyramine
ASJC Scopus subject areas
- Physiology
- Clinical Biochemistry
- Physiology (medical)