Effects of adrenergic blockers on central nervous system-mediated hyperglycemia in fed rats

Yasuo Kunoh, Akihisa Iguchi, Kazumasa Uemura, Hisayuki Miura, Tatsuo Tamagawa, Tadaaki Mano, Katunori Nonogaki, Minehiro Gotoh, Nobuo Sakamoto

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

We studied the effect of adrenergic blockade on hepatic venous hyperglycemia and the activation of a hepatic glycogenolytic enzyme, phosphorylase-a, in response to cerebral cholinergic activation. Neostigmine was injected into the third cerebral ventricle of bilaterally adrenodemedullectomized (ADMX) rats, while somatostatin and insulin were administered intravenously. Hepatic venous plasma glucose concentrations and hepatic phosphorylase-a activity were measured. Intracerebroventricular injection of neostigmine (5 × 10-8 mol) caused increases in hepatic venous glucose concentrations and hepatic phosphorylase-a activity. Both of these changes were prevented by intraperitoneal (IB) pretreatment with phentolamine (5 × 10-7, 1 × 10-6 mol) without the intervention of insulin secretion, but not by pretreatment with the α-antagonists antagonist phenoxybenzamine (1 × 10-6 mol), the β-adrenoreceptor antagonist propranolol (1 × 10-6 mol), the α1-antagonists prazosin or bunazosin (1 × 10-6 mol), the α2-antagonist yohimbine (1 × 10-6 mol), or prazosin (5 × 10-7 mol) plus yohimbine (5 × 10-7 mol). These results suggest that phentolamine prevented brain-mediated hepatic glycogenolysis by a mechanism that may not be classified pharmacologically as involving either α1- or α2-receptors.

Original languageEnglish
Pages (from-to)471-475
Number of pages5
JournalMetabolism
Volume41
Issue number5
DOIs
Publication statusPublished - 1992 May
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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