Effects of Adrenergic Agonists and Antagonists on Immediate Cutaneous Reactions in Bronchial Asthma

Tetsuhiro Ohmi, Suetsugu Mue, Makoto Takahashi, Shigeki Shibahara, Kohei Yamauchi, Gen Tamura, Satoru Fujimoto, Tamotsu Takishima, Hwei Chu Chen

Research output: Contribution to journalArticle

Abstract

Ohmi, T., Mue, S., Takahashi, M., Shibahara, S., Yamauchi, K., Tamura, G., Fujimoto, S., Chen, H.C. and Takishima, T. Effects of Adrenergic Agonists and Antagonists on Immediate Cutaneous Reactions in Bronchial Asthma. Tohoku J. exp. Med., 1979, 127 (2), p.197-198 — Asthmatic patients who showed an allergic skin reaction to house-dust antigen (HD) were injected intradermally with a mixture of HD and a various dose of isoproterenol (Isopr) or propranolol (Propr). In some cases Isopr clearly suppressed the formation of the wheal, but in some others Isopr did not much affect the allergic skin reaction. Also Propr increased markedly the skin reaction of some patients, or had little effect on it. The sensitivity of the skin of asthmatic patients to these drugs was closely correlated with the general response of the patients to adrenaline, such as changes in heart rate, diastolic blood pressure, blood glucose level, and blood triglyceride level. — adrenergic drugs; skin and systemic response; asthma.

Original languageEnglish
Pages (from-to)197-198
Number of pages2
Journalthe tohoku journal of experimental medicine
Volume127
Issue number2
DOIs
Publication statusPublished - 1979 Jan 1

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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    Ohmi, T., Mue, S., Takahashi, M., Shibahara, S., Yamauchi, K., Tamura, G., Fujimoto, S., Takishima, T., & Chu Chen, H. (1979). Effects of Adrenergic Agonists and Antagonists on Immediate Cutaneous Reactions in Bronchial Asthma. the tohoku journal of experimental medicine, 127(2), 197-198. https://doi.org/10.1620/tjem.127.197