Effects of 2-Nicotinamidethyl Nitrate (SG-75), a New Antianginal Drug, on the Cyclic AMP Phosphodiesterase Activity

Masao Endoh, Teruyuki Yanagisawa, Norio Taira

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

The effect of a potent coronary vasodilator, SG-75, on the purified cyclic AMP phosphodiesterase of the bovine heart was compared with that of papaverine. SG-75 inhibited the phosphodiesterase activity in a competitive manner, the IC50 being 10 mM. SG-75 was approximately 300 times less potent than papaverine in inhibiting the phosphodiesterase activity. Thus, it is unlikely that the phosphodiesterase inhibition by SG-75 is involved in its vasodilator action.

Original languageEnglish
Pages (from-to)199-201
Number of pages3
Journalthe tohoku journal of experimental medicine
Volume130
Issue number2
DOIs
Publication statusPublished - 1980

Keywords

  • 2-nicotinamidethyl nitrate
  • antianginal drug
  • coronary vasodilator
  • cyclic AMP phosphodiesterase
  • papaverine

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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