Abstract
The effect of a potent coronary vasodilator, SG-75, on the purified cyclic AMP phosphodiesterase of the bovine heart was compared with that of papaverine. SG-75 inhibited the phosphodiesterase activity in a competitive manner, the IC50 being 10 mM. SG-75 was approximately 300 times less potent than papaverine in inhibiting the phosphodiesterase activity. Thus, it is unlikely that the phosphodiesterase inhibition by SG-75 is involved in its vasodilator action.
Original language | English |
---|---|
Pages (from-to) | 199-201 |
Number of pages | 3 |
Journal | the tohoku journal of experimental medicine |
Volume | 130 |
Issue number | 2 |
DOIs | |
Publication status | Published - 1980 |
Keywords
- 2-nicotinamidethyl nitrate
- antianginal drug
- coronary vasodilator
- cyclic AMP phosphodiesterase
- papaverine
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)