Effects of β-sheet breaker peptide polymers on scrapie-infected mouse neuroblastoma cells and their affinities to prion protein fragment PrP(81-145)

Takehisa Oishi, Ken Ichi Hagiwara, Tomoya Kinumi, Yoshio Yamakawa, Masahiro Nishijima, Kazuhiko Nakamura, Hirokazu Arimoto

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Effects of β-sheet breaker peptide polymers on scrapie-infected mouse neuroblastoma cells and their affinities to prion protein fragment PrP (81-145) were studied. The dissociation constant was found to be fairly large, which provided evidence against the initial hypothesis. Surface plasmon resonance study indicated that direct binding between PrP(81-145) and the β-sheet breaker peptide was not specific and may not play a major role in the inhibition of PrP formation.

Original languageEnglish
Pages (from-to)2626-2629
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume1
Issue number15
DOIs
Publication statusPublished - 2003 Aug 7
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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