Effects of α-Tocopherol and Tocotrienols on Blood Pressure and Linoleic Acid Metabolism in the Spontaneously Hypertensive Rat (SHR)

Kazunori Koba, Kohji Abe, Ikuo Ikeda, Michihiro Sugano

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

Both α-tocopherol and a 1:1.7 mixture of α-tocopherol and tocotrienols at a 0.2% dietary level significantly depressed the age-related increase in the systolic blood pressure of spontaneously hypertensive rats (SHRs) after 3 weeks of feeding. The aortic production of prostacyclin was increased 1.5 times both by a-tocopherol and a tocotrienol mixture, suggesting a possible relevance to their hypotensive effect. These vitamins did not influence the A6- and J5-desaturase activities of liver microsomes, but fatty acid profiles of the liver phospholipids predicted a reduction of linoleic acid desaturation. These effects were in general more clear with tocotrienols than with a-tocopherol. Platelet aggregation by 5 μM ADP remained uninfluenced. Thus, tocotrienols may have effects on various lipid parameters somewhat different from those of α-tocopherol.

Original languageEnglish
Pages (from-to)1420-1423
Number of pages4
JournalBioscience, Biotechnology and Biochemistry
Volume56
Issue number9
DOIs
Publication statusPublished - 1992

Keywords

  • 6-keto-PGFla, 6-keto-prostaglandin Fla
  • CE, cholesterol ester
  • PC, phosphatidylcholine
  • PGI2, prostacyclin
  • PI, phosphatidylinositol
  • SHR, spontaneously hypertensive rat
  • TXA2, thromboxane A2
  • Toc3, α-tocopherol-tocotrienol mixture
  • Toe, DL-α-tocopherol

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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