Effectiveness of combination therapy with a sulfonylurea and once-daily insulin glargine in Japanese type 2 diabetic patients -Evaluation of the long-term (18 months) results of the combination therapy-

Hiromasa Goto, Takahisa Hirose, Tomoaki Shimizu, Tomoya Mita, Yasuhiro Igarashi, Yoshio Fujitani, Yasushi Tanaka, Hirotaka Watada, Ryuzo Kawamori

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7 Citations (Scopus)

Abstract

We have evaluated the long-term (18 months) effectiveness of the addition of once-daily insulin glargine (bedtime or morning) in the treatment of 44 type 2 diabetic patients (male/female: 27/17, mean HbA1c: 9.7 ± 1.6%) who had taken the maximum or a semi-maximum dose of sulfonylurea for more than a year but had not shown reduction of the HbA1c to below 7.5%. After 6 months, we divided the patients into two groups ; improved group, in which the HbA1c decreased to below 7.0% (n = 11, mean HbAc: 6.7 ± 0.3%), and the no-improvement group, in which sustained elevation of HbA1c at over 7.0% (n = 16, mean HbA1c: 8.3 ± 1.2%) was observed. In the improved group, the mean HbA1c after 18 months was still below 7.0% (6.9 ±0.6%; p < 0.001) and the dose of insulin glargine had not increased significantly. On the other hand, in the no-improvement group, no further improvement of the HbA1c value was observed between 6 and 18 months (8.3 ±1.3%) despite the significant increase in the dose of insulin glargine (9.3±4.8U ⇒ 14.3 ± 7.1U). These results suggest that this novel combination therapy shows long-term effectiveness, and may be recommended as a treatment of first-choice for patients who have difficulty in accepting intensive insulin therapy.

Original languageEnglish
Pages (from-to)591-597
Number of pages7
JournalJournal of the Japan Diabetes Society
Volume50
Issue number8
Publication statusPublished - 2007 Oct 22

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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