Effective chiral discrimination of tetravalent polyamines on the compaction of single DNA molecules

Yuko Yoshikawa; Naoki Umezawa; Yuki Imamura; Toshio Kanbe; Nobuki Kato; Kenichi Yoshikawa; Tadayuki Imanaka; Tsunehiko Higuchi

doi:10.1002/anie.201209144

Effective chiral discrimination of tetravalent polyamines on the compaction of single DNA molecules

Yuko Yoshikawa, Naoki Umezawa, Yuki Imamura, Toshio Kanbe, Nobuki Kato, Kenichi Yoshikawa, Tadayuki Imanaka, Tsunehiko Higuchi

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Normal doughnuts or lots of little ones? Among four stereoisomers of a tetravalent polyamine, the isomer pictured was the most potent at inducing DNA compaction, whereby the DNA molecules adopted a unique morphology of minitoroid clusters. The nonchiral polyamine spermine induced the formation of typical, larger toroidal structures.

Original language	English
Pages (from-to)	3712-3716
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	13
DOIs	https://doi.org/10.1002/anie.201209144
Publication status	Published - 2013 Mar 25
Externally published	Yes

Keywords

DNA structures
amines
chirality
fluorescence microscopy
single-molecule studies

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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Effective chiral discrimination of tetravalent polyamines on the compaction of single DNA molecules. / Yoshikawa, Yuko; Umezawa, Naoki; Imamura, Yuki; Kanbe, Toshio; Kato, Nobuki; Yoshikawa, Kenichi; Imanaka, Tadayuki; Higuchi, Tsunehiko.

In: Angewandte Chemie - International Edition, Vol. 52, No. 13, 25.03.2013, p. 3712-3716.

Research output: Contribution to journal › Article › peer-review

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AU - Imamura, Yuki

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AU - Kato, Nobuki

AU - Yoshikawa, Kenichi

AU - Imanaka, Tadayuki

AU - Higuchi, Tsunehiko

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KW - chirality

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Effective chiral discrimination of tetravalent polyamines on the compaction of single DNA molecules

Abstract

Keywords

ASJC Scopus subject areas

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