Effective chiral discrimination of tetravalent polyamines on the compaction of single DNA molecules

Yuko Yoshikawa; Naoki Umezawa; Yuki Imamura; Toshio Kanbe; Nobuki Kato; Kenichi Yoshikawa; Tadayuki Imanaka; Tsunehiko Higuchi

doi:10.1002/anie.201209144

Effective chiral discrimination of tetravalent polyamines on the compaction of single DNA molecules

Yuko Yoshikawa, Naoki Umezawa, Yuki Imamura, Toshio Kanbe, Nobuki Kato, Kenichi Yoshikawa, Tadayuki Imanaka, Tsunehiko Higuchi

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

Abstract

Normal doughnuts or lots of little ones? Among four stereoisomers of a tetravalent polyamine, the isomer pictured was the most potent at inducing DNA compaction, whereby the DNA molecules adopted a unique morphology of minitoroid clusters. The nonchiral polyamine spermine induced the formation of typical, larger toroidal structures.

Original language	English
Pages (from-to)	3712-3716
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	52
Issue number	13
DOIs	https://doi.org/10.1002/anie.201209144
Publication status	Published - 2013 Mar 25
Externally published	Yes

Keywords

DNA structures
amines
chirality
fluorescence microscopy
single-molecule studies

ASJC Scopus subject areas

Catalysis
Chemistry(all)

Access to Document

10.1002/anie.201209144

Cite this

@article{541672cb475d4e779a0a000086d02cb2,

title = "Effective chiral discrimination of tetravalent polyamines on the compaction of single DNA molecules",

abstract = "Normal doughnuts or lots of little ones? Among four stereoisomers of a tetravalent polyamine, the isomer pictured was the most potent at inducing DNA compaction, whereby the DNA molecules adopted a unique morphology of minitoroid clusters. The nonchiral polyamine spermine induced the formation of typical, larger toroidal structures.",

keywords = "DNA structures, amines, chirality, fluorescence microscopy, single-molecule studies",

author = "Yuko Yoshikawa and Naoki Umezawa and Yuki Imamura and Toshio Kanbe and Nobuki Kato and Kenichi Yoshikawa and Tadayuki Imanaka and Tsunehiko Higuchi",

year = "2013",

month = mar,

day = "25",

doi = "10.1002/anie.201209144",

language = "English",

volume = "52",

pages = "3712--3716",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "13",

}

TY - JOUR

T1 - Effective chiral discrimination of tetravalent polyamines on the compaction of single DNA molecules

AU - Yoshikawa, Yuko

AU - Umezawa, Naoki

AU - Imamura, Yuki

AU - Kanbe, Toshio

AU - Kato, Nobuki

AU - Yoshikawa, Kenichi

AU - Imanaka, Tadayuki

AU - Higuchi, Tsunehiko

PY - 2013/3/25

Y1 - 2013/3/25

N2 - Normal doughnuts or lots of little ones? Among four stereoisomers of a tetravalent polyamine, the isomer pictured was the most potent at inducing DNA compaction, whereby the DNA molecules adopted a unique morphology of minitoroid clusters. The nonchiral polyamine spermine induced the formation of typical, larger toroidal structures.

AB - Normal doughnuts or lots of little ones? Among four stereoisomers of a tetravalent polyamine, the isomer pictured was the most potent at inducing DNA compaction, whereby the DNA molecules adopted a unique morphology of minitoroid clusters. The nonchiral polyamine spermine induced the formation of typical, larger toroidal structures.

KW - DNA structures

KW - amines

KW - chirality

KW - fluorescence microscopy

KW - single-molecule studies

UR - http://www.scopus.com/inward/record.url?scp=84875332050&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84875332050&partnerID=8YFLogxK

U2 - 10.1002/anie.201209144

DO - 10.1002/anie.201209144

M3 - Article

C2 - 23440933

AN - SCOPUS:84875332050

VL - 52

SP - 3712

EP - 3716

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 13

ER -

Effective chiral discrimination of tetravalent polyamines on the compaction of single DNA molecules

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this