Effective chiral discrimination of tetravalent polyamines on the compaction of single DNA molecules

Yuko Yoshikawa, Naoki Umezawa, Yuki Imamura, Toshio Kanbe, Nobuki Kato, Kenichi Yoshikawa, Tadayuki Imanaka, Tsunehiko Higuchi

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Normal doughnuts or lots of little ones? Among four stereoisomers of a tetravalent polyamine, the isomer pictured was the most potent at inducing DNA compaction, whereby the DNA molecules adopted a unique morphology of minitoroid clusters. The nonchiral polyamine spermine induced the formation of typical, larger toroidal structures.

Original languageEnglish
Pages (from-to)3712-3716
Number of pages5
JournalAngewandte Chemie - International Edition
Volume52
Issue number13
DOIs
Publication statusPublished - 2013 Mar 25

Keywords

  • DNA structures
  • amines
  • chirality
  • fluorescence microscopy
  • single-molecule studies

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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