Effect of ZnO addition on bioactive CaO-SiO2-P2O5-CaF2 glass-ceramics containing apatite and wollastonite

M. Kamitakahara, C. Ohtsuki, H. Inada, M. Tanihara, T. Miyazaki

Research output: Contribution to journalArticlepeer-review

62 Citations (Scopus)


Some ceramics show bone-bonding ability, i.e. bioactivity. Apatite formation on ceramics is an essential condition to bring about direct bonding to living bone when implanted into bony defects. A controlled surface reaction of the ceramic is an important factor governing the bioactivity and biodegradation of the implanted ceramic. Among bioactive ceramics, glass-ceramic A-W containing apatite and wollastonite shows high bioactivity, as well as high mechanical strength. In this study, glass-ceramics containing zinc oxide were prepared by modification of the composition of the glass-ceramic A-W. Zinc oxide was selected to control the reactivity of the glass-ceramics since zinc is a trace element that shows stimulatory effects on bone formation. Glass-ceramics were prepared by heat treatment of glasses with the general composition: xZnO · (57.0 - x)CaO · 35.4SiO2 · 7.2P2O5 · 0.4CaF2 (where x = 0-14.2 mol.%). Addition of ZnO increased the chemical durability of the glass-ceramics, resulting in a decrease in the rate of apatite formation in a simulated body fluid. On the other hand, the release of zinc from the glass-ceramics increased with increasing ZnO content. Addition of ZnO may provide bioactive CaO-SiO2-P2O5-CaF2 glass-ceramics with the capacity for appropriate biodegradation, as well as enhancement of bone formation.

Original languageEnglish
Pages (from-to)467-471
Number of pages5
JournalActa Biomaterialia
Issue number4
Publication statusPublished - 2006 Jul
Externally publishedYes


  • Apatite
  • Bioactivity
  • Glass-ceramics
  • Simulated body fluid
  • Zinc

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology


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