Effect of vestibular labyrinth destruction on endocochlear potential and potassium concentration of the cochlea

Ryoukichi Ikeda, Kazuhiro Nakaya, Muneharu Yamazaki, Takeshi Oshima, Tetsuaki Kawase, Toshimitsu Kobayashi

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)

Abstract

Partial labyrinthectomy can result in maintenance of hearing under certain circumstances, and the mechanism of the hearing impairment caused by labyrinthectomy is unclear. We hypothesized that disruption of the membranous labyrinth results in electrical leakage and electrolyte imbalance. This study investigated the change in cochlear function by measurement of endocochlear potential (EP) and potassium concentration ([K+]) caused by vestibular labyrinth destruction in the acute phase. Hartley guinea pigs underwent lateral semicircular canal (LSCC) transection with suctioning of the perilymph, ampullectomy, or destruction of the LSCC, superior SCC, and lateral part of the vestibule. The EP and [K+] were monitored using double-barreled ion-selective microelectrodes in the second turn of cochlea. The EP showed little to mild change after LSCC transectioning or ampullectomy, but declined variously and drastically after vestibulotomy. The EP did not recover but [K+] partially recovered after vestibulotomy. Disturbance of the mechanism of cochlear function caused by vestibular labyrinth destruction may involve reduction in the [K+] concentration in the endolymph.

Original languageEnglish
Pages (from-to)90-95
Number of pages6
JournalHearing Research
Volume265
Issue number1-2
DOIs
Publication statusPublished - 2010 Jun

Keywords

  • Endocochlear potential
  • Labyrinthectomy
  • Potassium
  • Semicircular canal

ASJC Scopus subject areas

  • Sensory Systems

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