Effect of Vaccinium ashei reade leaves on angiotensin converting enzyme activity in vitro and on systolic blood pressure of spontaneously hypertensive rats in vivo

Hiroshi Sakaida, Koji Nagao, Kouki Higa, Bungo Shirouchi, Nao Inoue, Fumie Hidaka, Takanori Kai, Teruyoshi Yanagita

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The hypotensive effects of Vaccinium ashei reade (blueberry) leaves were studied in vitro and in vivo. Blueberry leaf showed a strong inhibitory effect on angiotensin-converting enzyme activity in vitro. Additionally, feeding of blueberry leaf suppressed the development of essential hypertension in spontaneously hypertensive rats in vivo. These results promise the use of blueberry leaf as a source of dietary hypotensive components.

Original languageEnglish
Pages (from-to)2335-2337
Number of pages3
JournalBioscience, Biotechnology and Biochemistry
Volume71
Issue number9
DOIs
Publication statusPublished - 2007 Nov 21
Externally publishedYes

Keywords

  • Angiotensin converting enzyme
  • Blueberry leaf
  • Spontaneously hypertensive rat
  • Vaccinium ashei reade

ASJC Scopus subject areas

  • Biotechnology
  • Analytical Chemistry
  • Biochemistry
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Organic Chemistry

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