Effect of uni-adrenalectomy on blood pressure in a patient with excessive adrenal 18-hydroxy-11-deoxycorticosterone production bilaterally

Minoru Kawamura; Masahiko Owada; Jun Ino; Takashi Sugawara; Tatsuya Nakano; Izumi Mochizuki; Tsutomu Sakuma; Toshie Segawa; Itaru Motegi; Hironobu Sasano

doi:10.2169/internalmedicine.42.507

Effect of uni-adrenalectomy on blood pressure in a patient with excessive adrenal 18-hydroxy-11-deoxycorticosterone production bilaterally

Minoru Kawamura, Masahiko Owada, Jun Ino, Takashi Sugawara, Tatsuya Nakano, Izumi Mochizuki, Tsutomu Sakuma, Toshie Segawa, Itaru Motegi, Hironobu Sasano

MED - Medical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

A 46-year-old woman was presented with mineralocorticoid excess syndrome and a large mass originating from the right adrenal gland. Clinical examination before right adrenalectomy revealed elevated serum concentrations of 18-hydroxy-11-deoxycorticosterone (18-OH-DOC) both systemically and in the adrenal veins bilaterally. Histopathological and immunohistochemical analyses of the surgical specimen demonstrated adrenal hyperplasia of outer fasciculata cells, and the presence of cystic mass. The adrenalectomy ameliorated her blood pressure (BP) from 156/96 mmHg to 148/87 mmHg with a concomitant increase of serum potassium concentration from 3.1 mEq/l to 3.5 mEq/l. These results suggest that uni-adrenalectomy is, at least in part, effective in amelio-rating not only BP but also potassium concentration in a patient of adrenal hyperplasia with excessive bilateral 18-OH-DOC production.

Original language	English
Pages (from-to)	507-512
Number of pages	6
Journal	Internal Medicine
Volume	42
Issue number	6
DOIs	https://doi.org/10.2169/internalmedicine.42.507
Publication status	Published - 2003 Jun 1

Keywords

Adrenal hyperplasia
Ambulatory blood pressure monitoring
Circadian rhythm
Immunohistochemistry
Potassium concentration

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.42.507

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Effect of uni-adrenalectomy on blood pressure in a patient with excessive adrenal 18-hydroxy-11-deoxycorticosterone production bilaterally. / Kawamura, Minoru; Owada, Masahiko; Ino, Jun; Sugawara, Takashi; Nakano, Tatsuya; Mochizuki, Izumi; Sakuma, Tsutomu; Segawa, Toshie; Motegi, Itaru; Sasano, Hironobu.

In: Internal Medicine, Vol. 42, No. 6, 01.06.2003, p. 507-512.

Research output: Contribution to journal › Article › peer-review

Kawamura, Minoru ; Owada, Masahiko ; Ino, Jun ; Sugawara, Takashi ; Nakano, Tatsuya ; Mochizuki, Izumi ; Sakuma, Tsutomu ; Segawa, Toshie ; Motegi, Itaru ; Sasano, Hironobu. / Effect of uni-adrenalectomy on blood pressure in a patient with excessive adrenal 18-hydroxy-11-deoxycorticosterone production bilaterally. In: Internal Medicine. 2003 ; Vol. 42, No. 6. pp. 507-512.

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abstract = "A 46-year-old woman was presented with mineralocorticoid excess syndrome and a large mass originating from the right adrenal gland. Clinical examination before right adrenalectomy revealed elevated serum concentrations of 18-hydroxy-11-deoxycorticosterone (18-OH-DOC) both systemically and in the adrenal veins bilaterally. Histopathological and immunohistochemical analyses of the surgical specimen demonstrated adrenal hyperplasia of outer fasciculata cells, and the presence of cystic mass. The adrenalectomy ameliorated her blood pressure (BP) from 156/96 mmHg to 148/87 mmHg with a concomitant increase of serum potassium concentration from 3.1 mEq/l to 3.5 mEq/l. These results suggest that uni-adrenalectomy is, at least in part, effective in amelio-rating not only BP but also potassium concentration in a patient of adrenal hyperplasia with excessive bilateral 18-OH-DOC production.",

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author = "Minoru Kawamura and Masahiko Owada and Jun Ino and Takashi Sugawara and Tatsuya Nakano and Izumi Mochizuki and Tsutomu Sakuma and Toshie Segawa and Itaru Motegi and Hironobu Sasano",

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AU - Sugawara, Takashi

AU - Nakano, Tatsuya

AU - Mochizuki, Izumi

AU - Sakuma, Tsutomu

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AU - Sasano, Hironobu

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AB - A 46-year-old woman was presented with mineralocorticoid excess syndrome and a large mass originating from the right adrenal gland. Clinical examination before right adrenalectomy revealed elevated serum concentrations of 18-hydroxy-11-deoxycorticosterone (18-OH-DOC) both systemically and in the adrenal veins bilaterally. Histopathological and immunohistochemical analyses of the surgical specimen demonstrated adrenal hyperplasia of outer fasciculata cells, and the presence of cystic mass. The adrenalectomy ameliorated her blood pressure (BP) from 156/96 mmHg to 148/87 mmHg with a concomitant increase of serum potassium concentration from 3.1 mEq/l to 3.5 mEq/l. These results suggest that uni-adrenalectomy is, at least in part, effective in amelio-rating not only BP but also potassium concentration in a patient of adrenal hyperplasia with excessive bilateral 18-OH-DOC production.

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