Effect of uni-adrenalectomy on blood pressure in a patient with excessive adrenal 18-hydroxy-11-deoxycorticosterone production bilaterally

Minoru Kawamura, Masahiko Owada, Jun Ino, Takashi Sugawara, Tatsuya Nakano, Izumi Mochizuki, Tsutomu Sakuma, Toshie Segawa, Itaru Motegi, Hironobu Sasano

Research output: Contribution to journalArticlepeer-review

Abstract

A 46-year-old woman was presented with mineralocorticoid excess syndrome and a large mass originating from the right adrenal gland. Clinical examination before right adrenalectomy revealed elevated serum concentrations of 18-hydroxy-11-deoxycorticosterone (18-OH-DOC) both systemically and in the adrenal veins bilaterally. Histopathological and immunohistochemical analyses of the surgical specimen demonstrated adrenal hyperplasia of outer fasciculata cells, and the presence of cystic mass. The adrenalectomy ameliorated her blood pressure (BP) from 156/96 mmHg to 148/87 mmHg with a concomitant increase of serum potassium concentration from 3.1 mEq/l to 3.5 mEq/l. These results suggest that uni-adrenalectomy is, at least in part, effective in amelio-rating not only BP but also potassium concentration in a patient of adrenal hyperplasia with excessive bilateral 18-OH-DOC production.

Original languageEnglish
Pages (from-to)507-512
Number of pages6
JournalInternal Medicine
Volume42
Issue number6
DOIs
Publication statusPublished - 2003 Jun 1

Keywords

  • Adrenal hyperplasia
  • Ambulatory blood pressure monitoring
  • Circadian rhythm
  • Immunohistochemistry
  • Potassium concentration

ASJC Scopus subject areas

  • Internal Medicine

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