Effect of trypsin and taurocholate on electrophysiological characteristics of isolated rat esophageal mucosa

Akihiro Iwatsuki, Iwao Sasaki, Yasuhiko Kamiyama, Hiroo Naito, Yuji Funayama, Seiki Matsuno

Research output: Contribution to journalArticlepeer-review

Abstract

Using Sprague-Dawley rats, the effect of trypsin and taurocholate on the electrophysiological characteristics of isolated esophageal mucosa was studied. After administration of trypsin, both the esophageal transepitherial potential difference (PD) and short circuit current (Isc) were increased and the esophageal transepitherial resistance (Rt) was significantly reduced. On the otherhand, there were no changes in these parameters after administration of taurocholate (TCA). Increased Isc after administration of trypsin was significantly reduced by amiloride administration. These results suggest that active ion transport in the esophageal mucosal cells is impaired by trypsin, but not bile acid in alkaline state. Compared to bile, pancreatic juice has more important role in the pathogenesis of reflux esophagitis after total gastrectomy.

Original languageEnglish
Pages (from-to)1051-1056
Number of pages6
JournalJapanese Journal of Gastroenterological Surgery
Volume31
Issue number5
DOIs
Publication statusPublished - 1998

Keywords

  • Alkaline reflux esophagitis
  • Bile acid
  • Total gastrectomy
  • Trypsin

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

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