TY - JOUR
T1 - Effect of trypsin and taurocholate on electrophysiological characteristics of isolated rat esophageal mucosa
AU - Iwatsuki, Akihiro
AU - Sasaki, Iwao
AU - Kamiyama, Yasuhiko
AU - Naito, Hiroo
AU - Funayama, Yuji
AU - Matsuno, Seiki
PY - 1998
Y1 - 1998
N2 - Using Sprague-Dawley rats, the effect of trypsin and taurocholate on the electrophysiological characteristics of isolated esophageal mucosa was studied. After administration of trypsin, both the esophageal transepitherial potential difference (PD) and short circuit current (Isc) were increased and the esophageal transepitherial resistance (Rt) was significantly reduced. On the otherhand, there were no changes in these parameters after administration of taurocholate (TCA). Increased Isc after administration of trypsin was significantly reduced by amiloride administration. These results suggest that active ion transport in the esophageal mucosal cells is impaired by trypsin, but not bile acid in alkaline state. Compared to bile, pancreatic juice has more important role in the pathogenesis of reflux esophagitis after total gastrectomy.
AB - Using Sprague-Dawley rats, the effect of trypsin and taurocholate on the electrophysiological characteristics of isolated esophageal mucosa was studied. After administration of trypsin, both the esophageal transepitherial potential difference (PD) and short circuit current (Isc) were increased and the esophageal transepitherial resistance (Rt) was significantly reduced. On the otherhand, there were no changes in these parameters after administration of taurocholate (TCA). Increased Isc after administration of trypsin was significantly reduced by amiloride administration. These results suggest that active ion transport in the esophageal mucosal cells is impaired by trypsin, but not bile acid in alkaline state. Compared to bile, pancreatic juice has more important role in the pathogenesis of reflux esophagitis after total gastrectomy.
KW - Alkaline reflux esophagitis
KW - Bile acid
KW - Total gastrectomy
KW - Trypsin
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U2 - 10.5833/jjgs.31.1051
DO - 10.5833/jjgs.31.1051
M3 - Article
AN - SCOPUS:54749094424
VL - 31
SP - 1051
EP - 1056
JO - Japanese Journal of Gastroenterological Surgery
JF - Japanese Journal of Gastroenterological Surgery
SN - 0386-9768
IS - 5
ER -