Effect of topical tafluprost on optic nerve head blood flow in patients with myopic disc type

Satoru Tsuda, Yu Yokoyama, Naoki Chiba, Naoko Aizawa, Yukihiro Shiga, Masayuki Yasuda, Shunji Yokokura, Takaaki Otomo, Nobuo Fuse, Toru Nakazawa

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39 Citations (Scopus)

Abstract

Purpose: To investigate the effect of topical tafluprost on optic disc blood flow in patients with myopic disc. Materials and Methods: Forty-eight eyes in 24 patients with a myopic disc type (oval shaped) optic disc tilted to the temporal, with a crescent peripapillary atrophy were included in this study. Twenty-eight eyes were diagnosed as normal tension glaucoma and 20 eyes were in normal subjects. None had any treatment for glaucoma. Average age was 45.3±11.9 years. One eye was treated with topical tafluprost and the fellow eye served as the control. Ocular blood flow was measured by laser speckle flowgraphy (LSFG-NAVI) at 30, 60, 90, and 120 minutes after tafluprost administration, and the mean blur rate (MBR) on the optic disc was analyzed. Blood pressure and intraocular pressure (IOP) were recorded. Results: In all subjects, topical tafluprost (a) significantly reduced IOP versus baseline from 60 minutes after treatment (baseline: 15.2±3.4mm Hg, 60min: 13.3±3.2mm Hg, P=0.001, 90min: 13.3±3.6mm Hg, P=0.002, 120 min: 13.7±3.4mm Hg, P=0.007); and (b) significantly increased the MBR versus baseline (60min: +4.3±6.6%, P=0.008, 90min: +5.0±4.9%, P<0.001, 120min: +6.7±7.0%, P<0.001). Conclusions: Topical tafluprost increased MBR in the optic nerve head and significantly reduced IOP, effects that may represent beneficial treatment for glaucoma patients with a myopic disc type.

Original languageEnglish
Pages (from-to)398-403
Number of pages6
JournalJournal of Glaucoma
Volume22
Issue number5
DOIs
Publication statusPublished - 2013 Jun

Keywords

  • Blood flow
  • Myopia
  • Normal tension glaucoma
  • Prostaglandin F2-a

ASJC Scopus subject areas

  • Ophthalmology

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