TY - JOUR
T1 - Effect of topical tafluprost on optic nerve head blood flow in patients with myopic disc type
AU - Tsuda, Satoru
AU - Yokoyama, Yu
AU - Chiba, Naoki
AU - Aizawa, Naoko
AU - Shiga, Yukihiro
AU - Yasuda, Masayuki
AU - Yokokura, Shunji
AU - Otomo, Takaaki
AU - Fuse, Nobuo
AU - Nakazawa, Toru
PY - 2013/6
Y1 - 2013/6
N2 - Purpose: To investigate the effect of topical tafluprost on optic disc blood flow in patients with myopic disc. Materials and Methods: Forty-eight eyes in 24 patients with a myopic disc type (oval shaped) optic disc tilted to the temporal, with a crescent peripapillary atrophy were included in this study. Twenty-eight eyes were diagnosed as normal tension glaucoma and 20 eyes were in normal subjects. None had any treatment for glaucoma. Average age was 45.3±11.9 years. One eye was treated with topical tafluprost and the fellow eye served as the control. Ocular blood flow was measured by laser speckle flowgraphy (LSFG-NAVI) at 30, 60, 90, and 120 minutes after tafluprost administration, and the mean blur rate (MBR) on the optic disc was analyzed. Blood pressure and intraocular pressure (IOP) were recorded. Results: In all subjects, topical tafluprost (a) significantly reduced IOP versus baseline from 60 minutes after treatment (baseline: 15.2±3.4mm Hg, 60min: 13.3±3.2mm Hg, P=0.001, 90min: 13.3±3.6mm Hg, P=0.002, 120 min: 13.7±3.4mm Hg, P=0.007); and (b) significantly increased the MBR versus baseline (60min: +4.3±6.6%, P=0.008, 90min: +5.0±4.9%, P<0.001, 120min: +6.7±7.0%, P<0.001). Conclusions: Topical tafluprost increased MBR in the optic nerve head and significantly reduced IOP, effects that may represent beneficial treatment for glaucoma patients with a myopic disc type.
AB - Purpose: To investigate the effect of topical tafluprost on optic disc blood flow in patients with myopic disc. Materials and Methods: Forty-eight eyes in 24 patients with a myopic disc type (oval shaped) optic disc tilted to the temporal, with a crescent peripapillary atrophy were included in this study. Twenty-eight eyes were diagnosed as normal tension glaucoma and 20 eyes were in normal subjects. None had any treatment for glaucoma. Average age was 45.3±11.9 years. One eye was treated with topical tafluprost and the fellow eye served as the control. Ocular blood flow was measured by laser speckle flowgraphy (LSFG-NAVI) at 30, 60, 90, and 120 minutes after tafluprost administration, and the mean blur rate (MBR) on the optic disc was analyzed. Blood pressure and intraocular pressure (IOP) were recorded. Results: In all subjects, topical tafluprost (a) significantly reduced IOP versus baseline from 60 minutes after treatment (baseline: 15.2±3.4mm Hg, 60min: 13.3±3.2mm Hg, P=0.001, 90min: 13.3±3.6mm Hg, P=0.002, 120 min: 13.7±3.4mm Hg, P=0.007); and (b) significantly increased the MBR versus baseline (60min: +4.3±6.6%, P=0.008, 90min: +5.0±4.9%, P<0.001, 120min: +6.7±7.0%, P<0.001). Conclusions: Topical tafluprost increased MBR in the optic nerve head and significantly reduced IOP, effects that may represent beneficial treatment for glaucoma patients with a myopic disc type.
KW - Blood flow
KW - Myopia
KW - Normal tension glaucoma
KW - Prostaglandin F2-a
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U2 - 10.1097/IJG.0b013e318237c8b3
DO - 10.1097/IJG.0b013e318237c8b3
M3 - Article
C2 - 23552835
AN - SCOPUS:84879152463
VL - 22
SP - 398
EP - 403
JO - Journal of Glaucoma
JF - Journal of Glaucoma
SN - 1057-0829
IS - 5
ER -