Effect of tiotropium/olodaterol on sedentary and active time in patients with COPD: Post hoc analysis of the VESUTO® study

Yoshiaki Minakata, Takashi Motegi, Jun Ueki, Yasuhiro Gon, Shuhei Nakamura, Tatsuhiko Anzai, Kazuto Hirata, Masakazu Ichinose

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

Background: Patients with COPD are less physically active. This post hoc analysis of a randomized, double-blind, active-controlled, crossover trial assessed the efficacy of once-daily tiotropium/olodaterol combination therapy versus tiotropium monotherapy in Japanese patients with COPD. Patients and methods: Patients were provided with a three-axis accelerometer to measure sedentary and active behavior defined as 1.0–1.5 metabolic equivalents (METs), ≥2.0 METs, and ≥3.0 METs, respectively. Of the 182 patients enrolled, 131 satisfied the conditions for the present analysis and were randomized to tiotropium monotherapy (n=62) or tiotropium/ olodaterol combination therapy (n=69). Results: Tiotropium/olodaterol combination therapy significantly reduced the duration of 1.0–1.5 MET activity by 8.64 mins (p=0.040) and significantly increased the duration of ≥2.0 MET and ≥3.0 MET activity by 6.51 mins (p=0.017) and 2.60 mins (p=0.008), respectively, compared with tiotropium alone. Subgroup analyses showed that better lung function, milder dyspnea, and higher levels of physical activity at baseline were associated with reduced sedentary time and increased duration of physical activity. Conclusion: Tiotropium/olodaterol combination therapy significantly reduced sedentary time and improved physical activity compared with tiotropium monotherapy. This trial was registered in ClinicalTrials.gov (NCT02629965).

Original languageEnglish
Pages (from-to)1789-1801
Number of pages13
JournalInternational Journal of COPD
Volume14
DOIs
Publication statusPublished - 2019

Keywords

  • COPD
  • Japanese
  • Physical activity
  • Sedentary behavior

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Health Policy
  • Public Health, Environmental and Occupational Health

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