Effect of Solvent on Nanoparticle Production of β-Carotene by a Supercritical Antisolvent Process

Hazuki Nerome, Siti Machmudah, Wahyudiono, Ryuichi Fukuzato, Takuma Higashiura, Hideki Kanda, Motonobu Goto

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Production of micro- to nano-sized particles of β-carotene was investigated by means of solution-enhanced dispersion by supercritical fluids (SEDS). β-Carotene was dissolved in dichloromethane (DCM), N,N-dimethylformamide (DMF), n-hexane, or ethyl acetate, and supercritical CO2 served as an antisolvent. The effects of the organic solvents, operating pressure, and temperature were examined. The morphologies of the particles produced by the SEDS were observed by field emission-scanning electron microscopy and particle sizes were determined by image analysis. Irregularly shaped microparticles were produced in the system with DCM and DMF solution. Plate-like microparticles were generated by using n-hexane solution and irregular nanoparticles by ethyl acetate solution. The optimum operating conditions were found to be ethyl acetate as solvent in a defined pressure and temperature range.

Original languageEnglish
Pages (from-to)1771-1777
Number of pages7
JournalChemical Engineering and Technology
Issue number10
Publication statusPublished - 2016 Oct 1
Externally publishedYes


  • Nanoparticle formation
  • Supercritical CO
  • Supercritical antisolvent
  • β-Carotene

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering


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