Effect of slow release nifedipine tablets in patients with essential hypertension

Y. Imai, K. Abe, M. Munakata, S. Sasaki, N. Minami, H. Sakuma, J. Hashimoto, N. Watanabe, M. Sakuma, H. Sekino, K. Imai, K. Yoshinaga

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Abstract

The antihypertensive effect of slow release nifedipine (CAS 21829-25-4) tablets (20 mg, Adalat®) administered once or twice daily was studied in patients with essential hypertension of WHO stage I or II. Ambulatory blood pressure was monitored by a finger volume oscillometric device every 5 min for 24 h before and during the treatment with nifedipine. Whether administered once or twice daily, nifedipine tablets did not change the pattern of circadian blood pressure variation; i.e. diurnal rise and nocturnal fall. Twice daily administration induced a significant downward shift in the blood pressure pattern. In other words, further hypotensive effect was observed during the night when the blood pressure was already low. On the other hand, administration once daily in the morning lowered daytime blood pressure without affecting blood pressure during the night. The duration of action of nifedipine tablets administered once daily as 12 h or more. In the acute experiment using 20 mg tablets of nifedipine, plasma concentration of nifedipine was well correlated with the percentage change in mean blood pressure. The minimal effective plasma concentration of nifedipine was estimated to be 13.4 ng/ml. However, in chronic treatment, nifedipine lowered blood pressure at the plasma concentration of 10 ng/ml. The results indicate that nifedipine tablets adninistered once daily provide an effective antihypertensive regimen for controlling daytime hypertension with minimal antihypertensive effect during the night.

Original languageEnglish
Pages (from-to)1434-1438
Number of pages5
JournalArzneimittel-Forschung/Drug Research
Volume42
Issue number12
Publication statusPublished - 1992

Keywords

  • Adalat®
  • CAS21829-25-4
  • antihypertensives
  • hypertension, essential
  • nifedipine, clinical studies

ASJC Scopus subject areas

  • Drug Discovery

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    Imai, Y., Abe, K., Munakata, M., Sasaki, S., Minami, N., Sakuma, H., Hashimoto, J., Watanabe, N., Sakuma, M., Sekino, H., Imai, K., & Yoshinaga, K. (1992). Effect of slow release nifedipine tablets in patients with essential hypertension. Arzneimittel-Forschung/Drug Research, 42(12), 1434-1438.