Effect of silicate incorporation in alpha-tricalcium phosphate on behaviors of osteoblast-like cells

Masanobu Kamitakahara, Takashi Shirato, Taishi Yokoi, Hideaki Matsubara, Yasuaki Shibata, Tohru Ikeda

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Silicate-containing alpha-tricalcium phosphate (α-TCP) ceramics are expected to be useful scaffolds for bone regeneration because α-TCP shows high biodegradability and silicate ions are expected to promote the bone formation. We previously revealed that the porous silicate-containing α-TCP granules provided earlier bone formation and showed lower biodegradability than the porous silicate-free α-TCP granules in vivo. In order to reveal the mechanism of the bone formation promoted by silicate incorporation, the proliferation and differentiation of osteoblast-like cells on the silicate-containing and silicate-free α-TCP ceramics were examined in vitro. The silicate incorporation in α-TCP promoted the differentiation of osteoblast-like cells, and it might be one of the factors to promote bone formation in vivo.

Original languageEnglish
Title of host publicationMultifunctional Bioceramics for Innovative Therapy
EditorsAhmed El-Ghannam
PublisherTrans Tech Publications Ltd
Pages90-94
Number of pages5
ISBN (Print)9783038357568
DOIs
Publication statusPublished - 2017
Event28th Annual Meeting of the International Society for Ceramics in Medicine, Bioceramics 2016 - Charlotte, United States
Duration: 2016 Oct 182016 Oct 21

Publication series

NameKey Engineering Materials
Volume720
ISSN (Print)1013-9826
ISSN (Electronic)1662-9795

Other

Other28th Annual Meeting of the International Society for Ceramics in Medicine, Bioceramics 2016
CountryUnited States
CityCharlotte
Period16/10/1816/10/21

Keywords

  • Alpha-tricalcium phosphate
  • Osteoblast
  • Silicate

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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