TY - JOUR
T1 - Effect of sesaminol on plasma and tissue α-tocopherol and α-tocotrienol concentrations in rats fed a vitamin E concentrate rich in tocotrienols
AU - Yamashita, Kanae
AU - Ikeda, Saiko
AU - Iizuka, Yoshie
AU - Ikeda, Ikuo
N1 - Funding Information:
This study was supported by a grant-in-aid for scientific research (C) from the Ministry of Education, Science and Culture Japan and the Science Research Promotion Fund from the Japan Private School Promotion Foundation.
PY - 2002
Y1 - 2002
N2 - We have shown that sesame lignans added to rat diet resulted in significantly greater plasma and tissue concentrations of α- and γ-tocopherol concentrations in supplemented rats than in rats without supplementation. In the present studies we examined whether sesaminol, a sesame lignan, enhances tocotrienol concentrations in plasma and tissues of rats fed diets containing a tocotrienol-rich fraction of palm oil (T-mix). In Experiment 1, effects of sesaminol on tocotrienol concentrations in plasma, liver, and kidney were evaluated in rats fed diets containing 20 mg/kg of T-mix (20T) and 50 mg/kg of T-mix (50T) with or without 0.1% sesaminol. Although the T-mix contained 23% α-tocopherol, 22% α-tocotrienol, and 34% γ-tocotrienol, α-tocopherol constituted most or all of the vitamin E in plasma and tissue (from 97% in kidney to 100% in plasma), with no or very little α-tocotrienol and no γ-tocotrienol at all. Addition of sesaminol to the T-mix resulted in significantly higher plasma, liver, and kidney α-tocopherol concentrations compared to values for T-mix alone. Further, T-mix with sesaminol resulted in significantly higher α-tocotrienol concentrations in kidney, although the concentration was very low. In Experiment 2, we examined whether sesaminol caused enhanced absorption of α-tocopherol and α-tocotrienol in a dosage regimen supplying T-mix and sesaminol on alternating days and observed significantly higher levels of α-tocopherol and α-tocotrienol in rats fed sesaminol, even without simultaneous intake, compared to those in rats without sesaminol. In Experiment 3, α-tocopherol was supplied to the stomach with and without sesaminol, and α-tocopherol concentrations in the lymph fluid were measured. α-Tocopherol concentrations were not different between groups. These results indicated that sesaminol produced markedly higher α-tocopherol concentrations in plasma and tissue and significantly greater α-tocotrienol concentrations in kidney and various other tissues, but the concentrations of α-tocotrienol were extremely low compared to those of α-tocopherol (Exps. 1 and 2). However, the sesaminol-induced increases of α-tocopherol and α-tocotrienol concentrations in plasma and tissue were not caused by their enhanced absorption since sesaminol did not enhance their absorption.
AB - We have shown that sesame lignans added to rat diet resulted in significantly greater plasma and tissue concentrations of α- and γ-tocopherol concentrations in supplemented rats than in rats without supplementation. In the present studies we examined whether sesaminol, a sesame lignan, enhances tocotrienol concentrations in plasma and tissues of rats fed diets containing a tocotrienol-rich fraction of palm oil (T-mix). In Experiment 1, effects of sesaminol on tocotrienol concentrations in plasma, liver, and kidney were evaluated in rats fed diets containing 20 mg/kg of T-mix (20T) and 50 mg/kg of T-mix (50T) with or without 0.1% sesaminol. Although the T-mix contained 23% α-tocopherol, 22% α-tocotrienol, and 34% γ-tocotrienol, α-tocopherol constituted most or all of the vitamin E in plasma and tissue (from 97% in kidney to 100% in plasma), with no or very little α-tocotrienol and no γ-tocotrienol at all. Addition of sesaminol to the T-mix resulted in significantly higher plasma, liver, and kidney α-tocopherol concentrations compared to values for T-mix alone. Further, T-mix with sesaminol resulted in significantly higher α-tocotrienol concentrations in kidney, although the concentration was very low. In Experiment 2, we examined whether sesaminol caused enhanced absorption of α-tocopherol and α-tocotrienol in a dosage regimen supplying T-mix and sesaminol on alternating days and observed significantly higher levels of α-tocopherol and α-tocotrienol in rats fed sesaminol, even without simultaneous intake, compared to those in rats without sesaminol. In Experiment 3, α-tocopherol was supplied to the stomach with and without sesaminol, and α-tocopherol concentrations in the lymph fluid were measured. α-Tocopherol concentrations were not different between groups. These results indicated that sesaminol produced markedly higher α-tocopherol concentrations in plasma and tissue and significantly greater α-tocotrienol concentrations in kidney and various other tissues, but the concentrations of α-tocotrienol were extremely low compared to those of α-tocopherol (Exps. 1 and 2). However, the sesaminol-induced increases of α-tocopherol and α-tocotrienol concentrations in plasma and tissue were not caused by their enhanced absorption since sesaminol did not enhance their absorption.
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U2 - 10.1007/s11745-002-0902-6
DO - 10.1007/s11745-002-0902-6
M3 - Article
C2 - 12030315
AN - SCOPUS:0036241711
VL - 37
SP - 351
EP - 358
JO - Lipids
JF - Lipids
SN - 0024-4201
IS - 4
ER -