Effect of selenite on renal toxicity and antitumor activity of cis-diamminedichloroplatinum in mice inoculated with ehrlich ascites tumor cell

Akira Naganuma, Masahiko Satoh, Nobumasa Imura

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

Effect of sodium selenite on renal toxicity and antitumor activity of cis-diamminedichloroplatinum (Cisplatin; CDDP) repeatedly administered to mice inoculated with Ehrlich ascites tumor cells were examined. Simultaneous repeated administration of selenite with CDDP markedly improved the growth depression, the renal toxicity indicated by blood urea nitrogen value and the diarrhea caused by CDDP, and inhibited the growth of Ehrlich ascites tumor cells cooperatively with CDDP. This results suggest that selenium compounds are useful for prevention of the toxic side effects of CDDP.

Original languageEnglish
Pages (from-to)217-220
Number of pages4
Journaljournal of pharmacobio-dynamics
Volume7
Issue number3
DOIs
Publication statusPublished - 1984 Jan 1

Keywords

  • antitumor activity
  • cis-diamminedichloroplatinum
  • diarrhea
  • mouse
  • renal toxicity
  • selenium

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Effect of selenite on renal toxicity and antitumor activity of cis-diamminedichloroplatinum in mice inoculated with ehrlich ascites tumor cell'. Together they form a unique fingerprint.

Cite this