Effect of recombinant human granulocyte colony-stimulating factor on survival in lethally irradiated mice

Y. Hosor, A. Kurishita, T. Ono, K. Sakamoto

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)

Abstract

Repeated injections of recombinant human granulocyte colony-stimulating factor (rhC-CSF) to lethally irradiated mice increased the rate of animal survival. Dose modification factor was 1.20 when 4.5 μg/mouse of rhC-CSF was given daily for 14 days after whole body irradiation. Haematological examinations revealed that rhC-CSF increased the number of bloodcirculating leukocytes, neutrophils, monocytes and erythrocytes, but not that of lymphocytes and thrombocytes. Spleen weight and number of endogenous spleen colonies were also increased by rhC-CSF treatment compared with the values for mice irradiated only.

Original languageEnglish
Pages (from-to)59-63
Number of pages5
JournalActa Oncologica
Volume31
Issue number1
DOIs
Publication statusPublished - 1992

Keywords

  • Colony-stimulating factor (G-CSF)
  • Granulocyte
  • Mice
  • Radiation
  • Survival
  • Total body

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Radiology Nuclear Medicine and imaging

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