Abstract
Rotator cuff tendon cells (RCC) derived from surgical samples showed fibroblast-like morphology. Histological staining demonstrated collagen secretion by RCC. Immunohistological findings revealed that RCC secreted type I and III collagen, but not type II collagen. In addition, the SDS-PAGE analysis suggested that RCC predominantly produced type I collagen. Basic fibroblast growth factor (bFGF) had a stimulatory effect on the proliferation of RCC dose-dependently up to 1 ng/ml. Administration of bFGF suppressed the secretion of collagens from RCC in a dose-dependent manner.
Original language | English |
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Pages (from-to) | 207-214 |
Number of pages | 8 |
Journal | Tohoku Journal of Experimental Medicine |
Volume | 198 |
Issue number | 4 |
DOIs | |
Publication status | Published - 2002 Dec 1 |
Externally published | Yes |
Keywords
- Basic fibroblast growth factor
- Collagen
- Primary culture
- Proliferation
- Rotator cuff tendon
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)