Effect of preparative conditions on crystallinity of apatite particles obtained from simulated body fluids

Mineo Hashizume; Yuka Nagasawa; Tomohiko Suzuki; Shin Kawashima; Masanobu Kamitakahara

doi:10.1016/j.colsurfb.2011.02.014

Effect of preparative conditions on crystallinity of apatite particles obtained from simulated body fluids

Mineo Hashizume, Yuka Nagasawa, Tomohiko Suzuki, Shin Kawashima, Masanobu Kamitakahara

ENV - Environmental Studies for Advanced Society

Research output: Contribution to journal › Article

14 Citations (Scopus)

Abstract

Preparation of colloidal hydroxyapatite (HAp) particles under body fluid conditions was investigated with focusing on the effect of preparative conditions on crystallinity of the resulting particles. Tris(hydroxymethyl)aminomethane was added to 1.5SBF (a solution having 1.5 times higher ion concentrations than those of a simulated body fluid, SBF) to increase the solution pH, which resulted in induction of homogeneous nucleation of HAp in the solution. Colloidal HAp particles having diameters about 300. nm were obtained. When the reaction was proceeded at 70 °C and the sample was dried by heating, it was effective to obtain HAp particles having high crystallinity. Experimental results support that remaining water in the sample contributed to increase HAp crystallinity.

Original language	English
Pages (from-to)	545-549
Number of pages	5
Journal	Colloids and Surfaces B: Biointerfaces
Volume	84
Issue number	2
DOIs	https://doi.org/10.1016/j.colsurfb.2011.02.014
Publication status	Published - 2011 Jun 1

Keywords

Colloidal particle
Homogeneous nucleation
Hydroxyapatite (HAp)
Simulated body fluid (SBF)

ASJC Scopus subject areas

Biotechnology
Surfaces and Interfaces
Physical and Theoretical Chemistry
Colloid and Surface Chemistry

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10.1016/j.colsurfb.2011.02.014

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abstract = "Preparation of colloidal hydroxyapatite (HAp) particles under body fluid conditions was investigated with focusing on the effect of preparative conditions on crystallinity of the resulting particles. Tris(hydroxymethyl)aminomethane was added to 1.5SBF (a solution having 1.5 times higher ion concentrations than those of a simulated body fluid, SBF) to increase the solution pH, which resulted in induction of homogeneous nucleation of HAp in the solution. Colloidal HAp particles having diameters about 300. nm were obtained. When the reaction was proceeded at 70 °C and the sample was dried by heating, it was effective to obtain HAp particles having high crystallinity. Experimental results support that remaining water in the sample contributed to increase HAp crystallinity.",

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AU - Suzuki, Tomohiko

AU - Kawashima, Shin

AU - Kamitakahara, Masanobu

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