Effect of octacalcium phosphate-based bone substitute materials on oriented bone regeneration

Osamu Suzuki, Takahisa Anada

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The characteristics and the biological responses of octacalcium phosphate (OCP) crystals, obtained in the presence of natural polymers, were summarized based on our studies reported. OCP obtained with collagen molecules in the solution had a plate-like morphology while OCP obtained with gelatin molecules in the solution exhibited elongated morphology toward long axis of the crystals. Oriented bone matrix formation was observed by the OCP inclusion in gelatin sponge in a critical-sized rat calvaria defect within the implantation periods around 8 weeks. It seems likely that specific crystal property of OCP obtained in distinct preparation conditions may affect bone tissue response probably through the modulation of OCP crystal characteristics.

Original languageEnglish
Title of host publicationBioceramics - 29th Symposium and Annual Meeting of the International Society for Ceramics in Medicine
EditorsChristian Rey, Christele Combes, Christophe Drouet
PublisherTrans Tech Publications Ltd
Pages223-227
Number of pages5
ISBN (Print)9783035712209
DOIs
Publication statusPublished - 2017 Jan 1
Event29th Symposium and Annual Meeting of the International Society for Ceramics in Medicine, ISCM 2017 - Toulouse, France
Duration: 2017 Oct 252017 Oct 27

Publication series

NameKey Engineering Materials
Volume758 KEM
ISSN (Print)1013-9826
ISSN (Electronic)1662-9795

Other

Other29th Symposium and Annual Meeting of the International Society for Ceramics in Medicine, ISCM 2017
CountryFrance
CityToulouse
Period17/10/2517/10/27

Keywords

  • Bioactivity
  • Crystal modulation
  • Matrix proteins
  • Octacalcium phosphate
  • Regenerated bone

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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  • Cite this

    Suzuki, O., & Anada, T. (2017). Effect of octacalcium phosphate-based bone substitute materials on oriented bone regeneration. In C. Rey, C. Combes, & C. Drouet (Eds.), Bioceramics - 29th Symposium and Annual Meeting of the International Society for Ceramics in Medicine (pp. 223-227). (Key Engineering Materials; Vol. 758 KEM). Trans Tech Publications Ltd. https://doi.org/10.4028/www.scientific.net/KEM.758.223