Effect of nitrous oxide on spike activity during epilepsy surgery

Y. Sato, K. Sato, H. Shamoto, M. Kato, T. Yoshimoto

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)


There are controversies over the effect of nitous oxide on the electrocorticograms in patients with epilepsy. To clarify the effect of nitrous oxide on electrocorticograms, spike activities were compared with and without nitrous oxide under neuroleptoanesthesia in 10 patients with intractable epilepsy during surgery. Spikes decreased with nitous oxide significantly (P < 0.01) and disappeared in 3 cases. We conclude that discontinuation of nitrous oxide should be taken into consideration during electrocorticographic monitoring in epilepsy surgery.

Original languageEnglish
Pages (from-to)1213-1216
Number of pages4
JournalActa neurochirurgica
Issue number12
Publication statusPublished - 2001
Externally publishedYes


  • Electrocorticogram
  • Epilepsy
  • Nitrous oxide

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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