Effect of nicotine on cognitive disturbance in animals with acetylcholine deficient brain

H. Sasaki, K. I. Meguro, Y. Matsuzaki, C. Doi, S. Yamaguchi, T. Nakamura, T. Aoki, K. Sekizawa, Y. Shimizu

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of nicotine on learning disturbance was tested in rats fed with a choline-deficient diet (Ch free) or in senescence-accelerated mice (SAM). Concentration of acetylcholine in the brain was significantly lower in rats fed with Ch free and SAM. Passive avoidance learning shows that rats fed with Ch free and SAM showed significantly impaired learning, compared to controls. Nicotine (0.04 mg/kg) administered intraperitonealy significantly improved learning in animals with learning disturbances, as well as in controls. Vitamin B12 facilitated acetylcholine synthesis or release in the brain and improved the cognitive disturbance. We therefore suggest that acetylcholine contributes to learning and that nicotine may improve learning in an acetylcholine deprived rats.

Original languageEnglish
Pages (from-to)143-147
Number of pages5
JournalJapanese Journal of Psychopharmacology
Volume13
Issue number3
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Medicine(all)

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