Effect of Motilin on Colonic Motor Activity in the Interdigestive State in Conscious Dogs

Chikashi Shibata, Iwao Sasaki, Hiroo Naito, Michinaga Takahashi, Takashi Doi, Noriya Ohtani, Kaori Koyama, Seiki Matsuno

Research output: Contribution to journalArticlepeer-review

8 Citations (Scopus)

Abstract

The aim of the present study was to investigate the effect of motilin at various doses on colonic motility in the interdigestive state. Colonic motility was investigated in five dogs equipped with strain gauge force transducers on the gastric antrum, and on the proximal, middle, and distal colon. Exogenously infused motilin (0.2, 0.5, 1.0 and 2.0 μg/kg-hr) dose-dependently increased colonic motility, but the doses of motilin that significantly enhanced colonic motility were 1.0 and 2.0 μg/kg-hr in all areas of the colon. Motilin at 0.2 μg/kg-hr increased the plasma motilin concentration to almost equal to the physiological peak values. The excitatory effect of motilin (2.0 μg/kg-hr) was abolished by atropine but was not affected by hexamethonium. These results indicate that exogenously infused motilin, which increased plasma motilin concenration to above the physiological peak level, stimulated colonic motility by affecting postsynaptic cholinergic neurons.

Original languageEnglish
Pages (from-to)53-60
Number of pages8
JournalTohoku Journal of Experimental Medicine
Volume176
Issue number1
DOIs
Publication statusPublished - 1995

Keywords

  • cholinergic neurons
  • colonic motor complexes
  • motilin

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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