TY - JOUR
T1 - Effect of Motilin on Colonic Motor Activity in the Interdigestive State in Conscious Dogs
AU - Shibata, Chikashi
AU - Sasaki, Iwao
AU - Naito, Hiroo
AU - Takahashi, Michinaga
AU - Doi, Takashi
AU - Ohtani, Noriya
AU - Koyama, Kaori
AU - Matsuno, Seiki
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1995
Y1 - 1995
N2 - The aim of the present study was to investigate the effect of motilin at various doses on colonic motility in the interdigestive state. Colonic motility was investigated in five dogs equipped with strain gauge force transducers on the gastric antrum, and on the proximal, middle, and distal colon. Exogenously infused motilin (0.2, 0.5, 1.0 and 2.0 μg/kg-hr) dose-dependently increased colonic motility, but the doses of motilin that significantly enhanced colonic motility were 1.0 and 2.0 μg/kg-hr in all areas of the colon. Motilin at 0.2 μg/kg-hr increased the plasma motilin concentration to almost equal to the physiological peak values. The excitatory effect of motilin (2.0 μg/kg-hr) was abolished by atropine but was not affected by hexamethonium. These results indicate that exogenously infused motilin, which increased plasma motilin concenration to above the physiological peak level, stimulated colonic motility by affecting postsynaptic cholinergic neurons.
AB - The aim of the present study was to investigate the effect of motilin at various doses on colonic motility in the interdigestive state. Colonic motility was investigated in five dogs equipped with strain gauge force transducers on the gastric antrum, and on the proximal, middle, and distal colon. Exogenously infused motilin (0.2, 0.5, 1.0 and 2.0 μg/kg-hr) dose-dependently increased colonic motility, but the doses of motilin that significantly enhanced colonic motility were 1.0 and 2.0 μg/kg-hr in all areas of the colon. Motilin at 0.2 μg/kg-hr increased the plasma motilin concentration to almost equal to the physiological peak values. The excitatory effect of motilin (2.0 μg/kg-hr) was abolished by atropine but was not affected by hexamethonium. These results indicate that exogenously infused motilin, which increased plasma motilin concenration to above the physiological peak level, stimulated colonic motility by affecting postsynaptic cholinergic neurons.
KW - cholinergic neurons
KW - colonic motor complexes
KW - motilin
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U2 - 10.1620/tjem.176.53
DO - 10.1620/tjem.176.53
M3 - Article
C2 - 7482519
AN - SCOPUS:0029097856
VL - 176
SP - 53
EP - 60
JO - Tohoku Journal of Experimental Medicine
JF - Tohoku Journal of Experimental Medicine
SN - 0040-8727
IS - 1
ER -