Effect of Metallothionein-III on mercury-induced chemokine gene expression

Jin Yong Lee, Maki Tokumoto, Gi Wook Hwang, Min Seok Kim, Tsutomu Takahashi, Akira Naganuma, Minoru Yoshida, Masahiko Satoh

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Mercury compounds are known to cause central nervous system disorders; however the detailed molecular mechanisms of their actions remain unclear. Methylmercury increases the expression of several chemokine genes, specifically in the brain, while metallothionein-III (MT-III) has a protective role against various brain diseases. In this study, we investigated the involvement of MT-III in chemokine gene expression changes in response to methylmercury and mercury vapor in the cerebrum and cerebellum of wild-type mice and MT-III null mice. No difference in mercury concentration was observed between the wild-type mice and MT-III null mice in any brain tissue examined. The expression of Ccl3 in the cerebrum and of Cxcl10 in the cerebellum was increased by methylmercury in the MT-III null but not the wild-type mice. The expression of Ccl7 in the cerebellum was increased by mercury vapor in the MT-III null mice but not the wild-type mice. However, the expression of Ccl12 and Cxcl12 was increased in the cerebrum by methylmercury only in the wild-type mice and the expression of Ccl3 in the cerebellum was increased by mercury vapor only in the wild-type mice. These results indicate that MT-III does not affect mercury accumulation in the brain, but that it affects the expression of some chemokine genes in response to mercury compounds.

Original languageEnglish
Article number48
JournalToxics
Volume6
Issue number3
DOIs
Publication statusPublished - 2018 Aug 12

Keywords

  • Chemokine
  • Mercury vapor
  • Metallothionein-III
  • Methylmercury

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis
  • Chemical Health and Safety

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