Effect of mCOUP-TF1 deficiency on the glossopharyngeal and vagal sensory ganglia

H. Ichikawa, S. C. Lin, S. Y. Tsai, M. J. Tsai, T. Sugimoto

Research output: Contribution to journalArticle

Abstract

Immunohistochemistry for calcitonin gene-related peptide (CGRP), tyrosine hydroxylase and calbindin D-28k was performed on the glossopharyngeal and vagal ganglia in mCOUP-TFI knockout mice to know the effect of its deficiency on different types of primary sensory neurons. In wild type and heterozygous mice, the glossopharyngeal and vagal ganglia contained abundant CGRP-, tyrosine hydroxylase- and calbindin D-28k-immunoreactive (IR) neurons. In the ganglia of mCOUP-TFI knockout mice, a 38% decrease of CGRP-IR neurons was detected. However, the number of tyrosine hydroxylase- or calbindin D-28k-neurons was not altered by the mCOUP-TFI deficiency. In the tongue of knockout mice, the number of CGRP-IR nerve fibers decreased compared to wild-type and heterozygous mice. The development of CGRP-IR petrosal neurons, which supply innervation of the tongue, may depend on mCOUP-TFI.

Original languageEnglish
Pages (from-to)247-250
Number of pages4
JournalBrain research
Volume1014
Issue number1-2
DOIs
Publication statusPublished - 2004 Jul 16
Externally publishedYes

Keywords

  • Calbindin D-28k
  • Calcitonin gene-related peptide
  • Knockout mouse
  • Petrosal neuron
  • Sensory systems
  • Somatic and visceral afferents
  • Tyrosine hydroxylase
  • mCOUP-TF

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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