Effect of maternal selenium deficiency on the teratogenicity of methylmercury

Noriko Nishikido, Yasuko Satoh, Akira Naganuma, Nobumasa Imura

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

The teratogenicity of methylmercury was examined in selenium-deficient and selenium-sufficient mice of the ICR strain. A single oral dose of 75 μmol kg of methylmercuric chloride (MMC) on day 10, 11 or 12 of gestation caused similar incidences of a cleft palate in the selenium-deficient and seleniumsufficient mice. The treatment on day 11 led to the highest incidence of a cleft palate in both groups. These results suggest that a maternal selenium deficiency has no effect on the incidence or on the critical gestalional period for an MMC-induced cleft palate.

Original languageEnglish
Pages (from-to)153-157
Number of pages5
JournalToxicology Letters
Volume40
Issue number2
DOIs
Publication statusPublished - 1988 Feb

Keywords

  • Dietary selenium deficiency
  • Fetotoxicity of methylmercury
  • Methylmercury-induced cleft palate

ASJC Scopus subject areas

  • Toxicology

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