Effect of maternal selenium deficiency on the teratogenicity of methylmercury

Noriko Nishikido; Yasuko Satoh; Akira Naganuma; Nobumasa Imura

doi:10.1016/0378-4274(88)90156-7

Effect of maternal selenium deficiency on the teratogenicity of methylmercury

Noriko Nishikido, Yasuko Satoh, Akira Naganuma, Nobumasa Imura

PHA - Life and Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

The teratogenicity of methylmercury was examined in selenium-deficient and selenium-sufficient mice of the ICR strain. A single oral dose of 75 μmol kg of methylmercuric chloride (MMC) on day 10, 11 or 12 of gestation caused similar incidences of a cleft palate in the selenium-deficient and seleniumsufficient mice. The treatment on day 11 led to the highest incidence of a cleft palate in both groups. These results suggest that a maternal selenium deficiency has no effect on the incidence or on the critical gestalional period for an MMC-induced cleft palate.

Original language	English
Pages (from-to)	153-157
Number of pages	5
Journal	Toxicology Letters
Volume	40
Issue number	2
DOIs	https://doi.org/10.1016/0378-4274(88)90156-7
Publication status	Published - 1988 Feb

Keywords

Dietary selenium deficiency
Fetotoxicity of methylmercury
Methylmercury-induced cleft palate

ASJC Scopus subject areas

Toxicology

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10.1016/0378-4274(88)90156-7

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title = "Effect of maternal selenium deficiency on the teratogenicity of methylmercury",

abstract = "The teratogenicity of methylmercury was examined in selenium-deficient and selenium-sufficient mice of the ICR strain. A single oral dose of 75 μmol kg of methylmercuric chloride (MMC) on day 10, 11 or 12 of gestation caused similar incidences of a cleft palate in the selenium-deficient and seleniumsufficient mice. The treatment on day 11 led to the highest incidence of a cleft palate in both groups. These results suggest that a maternal selenium deficiency has no effect on the incidence or on the critical gestalional period for an MMC-induced cleft palate.",

keywords = "Dietary selenium deficiency, Fetotoxicity of methylmercury, Methylmercury-induced cleft palate",

author = "Noriko Nishikido and Yasuko Satoh and Akira Naganuma and Nobumasa Imura",

year = "1988",

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T1 - Effect of maternal selenium deficiency on the teratogenicity of methylmercury

AU - Nishikido, Noriko

AU - Satoh, Yasuko

AU - Naganuma, Akira

AU - Imura, Nobumasa

PY - 1988/2

Y1 - 1988/2

N2 - The teratogenicity of methylmercury was examined in selenium-deficient and selenium-sufficient mice of the ICR strain. A single oral dose of 75 μmol kg of methylmercuric chloride (MMC) on day 10, 11 or 12 of gestation caused similar incidences of a cleft palate in the selenium-deficient and seleniumsufficient mice. The treatment on day 11 led to the highest incidence of a cleft palate in both groups. These results suggest that a maternal selenium deficiency has no effect on the incidence or on the critical gestalional period for an MMC-induced cleft palate.

AB - The teratogenicity of methylmercury was examined in selenium-deficient and selenium-sufficient mice of the ICR strain. A single oral dose of 75 μmol kg of methylmercuric chloride (MMC) on day 10, 11 or 12 of gestation caused similar incidences of a cleft palate in the selenium-deficient and seleniumsufficient mice. The treatment on day 11 led to the highest incidence of a cleft palate in both groups. These results suggest that a maternal selenium deficiency has no effect on the incidence or on the critical gestalional period for an MMC-induced cleft palate.

KW - Dietary selenium deficiency

KW - Fetotoxicity of methylmercury

KW - Methylmercury-induced cleft palate

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