Effect of maternal selenium deficiency on the teratogenicity of methylmercury

Noriko Nishikido; Yasuko Satoh; Akira Naganuma; Nobumasa Imura

doi:10.1016/0378-4274(88)90156-7

Effect of maternal selenium deficiency on the teratogenicity of methylmercury

Noriko Nishikido, Yasuko Satoh, Akira Naganuma, Nobumasa Imura

PHA - Life and Pharmaceutical Science

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

The teratogenicity of methylmercury was examined in selenium-deficient and selenium-sufficient mice of the ICR strain. A single oral dose of 75 μmol kg of methylmercuric chloride (MMC) on day 10, 11 or 12 of gestation caused similar incidences of a cleft palate in the selenium-deficient and seleniumsufficient mice. The treatment on day 11 led to the highest incidence of a cleft palate in both groups. These results suggest that a maternal selenium deficiency has no effect on the incidence or on the critical gestalional period for an MMC-induced cleft palate.

Original language	English
Pages (from-to)	153-157
Number of pages	5
Journal	Toxicology Letters
Volume	40
Issue number	2
DOIs	https://doi.org/10.1016/0378-4274(88)90156-7
Publication status	Published - 1988 Feb

Keywords

Dietary selenium deficiency
Fetotoxicity of methylmercury
Methylmercury-induced cleft palate

ASJC Scopus subject areas

Toxicology

Access to Document

10.1016/0378-4274(88)90156-7

Cite this

@article{95bd83de1dd6462fa7dbbcb7fb41d42b,

title = "Effect of maternal selenium deficiency on the teratogenicity of methylmercury",

abstract = "The teratogenicity of methylmercury was examined in selenium-deficient and selenium-sufficient mice of the ICR strain. A single oral dose of 75 μmol kg of methylmercuric chloride (MMC) on day 10, 11 or 12 of gestation caused similar incidences of a cleft palate in the selenium-deficient and seleniumsufficient mice. The treatment on day 11 led to the highest incidence of a cleft palate in both groups. These results suggest that a maternal selenium deficiency has no effect on the incidence or on the critical gestalional period for an MMC-induced cleft palate.",

keywords = "Dietary selenium deficiency, Fetotoxicity of methylmercury, Methylmercury-induced cleft palate",

author = "Noriko Nishikido and Yasuko Satoh and Akira Naganuma and Nobumasa Imura",

note = "Funding Information: This study was supported in part by a grant from Uehara Memorial Japan.",

year = "1988",

month = feb,

doi = "10.1016/0378-4274(88)90156-7",

language = "English",

volume = "40",

pages = "153--157",

journal = "Toxicology Letters",

issn = "0378-4274",

publisher = "Elsevier BV",

number = "2",

}

TY - JOUR

T1 - Effect of maternal selenium deficiency on the teratogenicity of methylmercury

AU - Nishikido, Noriko

AU - Satoh, Yasuko

AU - Naganuma, Akira

AU - Imura, Nobumasa

N1 - Funding Information: This study was supported in part by a grant from Uehara Memorial Japan.

PY - 1988/2

Y1 - 1988/2

N2 - The teratogenicity of methylmercury was examined in selenium-deficient and selenium-sufficient mice of the ICR strain. A single oral dose of 75 μmol kg of methylmercuric chloride (MMC) on day 10, 11 or 12 of gestation caused similar incidences of a cleft palate in the selenium-deficient and seleniumsufficient mice. The treatment on day 11 led to the highest incidence of a cleft palate in both groups. These results suggest that a maternal selenium deficiency has no effect on the incidence or on the critical gestalional period for an MMC-induced cleft palate.

AB - The teratogenicity of methylmercury was examined in selenium-deficient and selenium-sufficient mice of the ICR strain. A single oral dose of 75 μmol kg of methylmercuric chloride (MMC) on day 10, 11 or 12 of gestation caused similar incidences of a cleft palate in the selenium-deficient and seleniumsufficient mice. The treatment on day 11 led to the highest incidence of a cleft palate in both groups. These results suggest that a maternal selenium deficiency has no effect on the incidence or on the critical gestalional period for an MMC-induced cleft palate.

KW - Dietary selenium deficiency

KW - Fetotoxicity of methylmercury

KW - Methylmercury-induced cleft palate

UR - http://www.scopus.com/inward/record.url?scp=0023906066&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023906066&partnerID=8YFLogxK

U2 - 10.1016/0378-4274(88)90156-7

DO - 10.1016/0378-4274(88)90156-7

M3 - Article

C2 - 3341056

AN - SCOPUS:0023906066

VL - 40

SP - 153

EP - 157

JO - Toxicology Letters

JF - Toxicology Letters

SN - 0378-4274

IS - 2

ER -

Effect of maternal selenium deficiency on the teratogenicity of methylmercury

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this