Effect of mabuterol on tracheal mucociliary clearance of magnetized iron particles in anesthetized dogs

M. Nakamura; M. Yamaya; T. Fukushima; K. Sekizawa; H. Sasaki; T. Takishima

doi:10.1159/000195893

Effect of mabuterol on tracheal mucociliary clearance of magnetized iron particles in anesthetized dogs

M. Nakamura, M. Yamaya, T. Fukushima, K. Sekizawa, H. Sasaki, T. Takishima

Medicine

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

We studied the effect of mabuterol on the tracheal mucociliary clearance of magnetized iron particles in anesthetized dogs. A catheter was inserted directly into the trachea through the mouth and 0.05 ml of saline solution with 30 mg of Fe₃O₄ was instilled into the trachea. After magnetization from outside the chest wall, the remanent magnetic field (RMF) strength generated in the trachea was sequentially measured with a flux-gate magnetometer. The decay of RMF immediately after sequential magnetization showed a clearance of Fe₃O₄ particles. Mabuterol (10 μg/kg) increased clearance as much as isoproterenol (10 μg/kg) 30 min after intravenous injection relative to control measurement (p<0.01). These results suggest that mabuterol is useful to promote clearance.

Original language	English
Pages (from-to)	33-36
Number of pages	4
Journal	Respiration
Volume	58
Issue number	1
DOIs	https://doi.org/10.1159/000195893
Publication status	Published - 1991

Keywords

airway mucociliary transport
iron particles
remanent magnetic field
β-stimulant

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine

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abstract = "We studied the effect of mabuterol on the tracheal mucociliary clearance of magnetized iron particles in anesthetized dogs. A catheter was inserted directly into the trachea through the mouth and 0.05 ml of saline solution with 30 mg of Fe3O4 was instilled into the trachea. After magnetization from outside the chest wall, the remanent magnetic field (RMF) strength generated in the trachea was sequentially measured with a flux-gate magnetometer. The decay of RMF immediately after sequential magnetization showed a clearance of Fe3O4 particles. Mabuterol (10 μg/kg) increased clearance as much as isoproterenol (10 μg/kg) 30 min after intravenous injection relative to control measurement (p<0.01). These results suggest that mabuterol is useful to promote clearance.",

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AU - Nakamura, M.

AU - Yamaya, M.

AU - Fukushima, T.

AU - Sekizawa, K.

AU - Sasaki, H.

AU - Takishima, T.

PY - 1991

Y1 - 1991

N2 - We studied the effect of mabuterol on the tracheal mucociliary clearance of magnetized iron particles in anesthetized dogs. A catheter was inserted directly into the trachea through the mouth and 0.05 ml of saline solution with 30 mg of Fe3O4 was instilled into the trachea. After magnetization from outside the chest wall, the remanent magnetic field (RMF) strength generated in the trachea was sequentially measured with a flux-gate magnetometer. The decay of RMF immediately after sequential magnetization showed a clearance of Fe3O4 particles. Mabuterol (10 μg/kg) increased clearance as much as isoproterenol (10 μg/kg) 30 min after intravenous injection relative to control measurement (p<0.01). These results suggest that mabuterol is useful to promote clearance.

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KW - β-stimulant

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Effect of mabuterol on tracheal mucociliary clearance of magnetized iron particles in anesthetized dogs

Abstract

Keywords

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