Effect of Loop Diuretics on Otolith Function

Tetsuaki Kawase, Jun Kusakari, Kazutomo Kawamoto

Research output: Contribution to journalArticle

Abstract

It has been reported that ethacrynic acid (ETA) reduces the ampullar and saccular endolymphatic potentials (EP), whereas furosemide inhibits only saccular EP and has no effect on ampullar EP. In 1979, one of the present authors (J. Kusakari) reported that the nystagmus produced by stimulation of the peripheral organ was greatly inhibited by ETA. In the present study we examined the effect of EP depression on the otolith organ. Normal and unilateral labyrinthectomized albino guinea pigs were fixed on a tilt table and counter-rolling (GR) of the eyes was measured by the photographic method. ETA (50,100,150 mg/kg) and furosemide (100 mg/kg) were injected intravenously, and measurements were recorded for 30~150 minutes. Although 50 mg/kg ETA and 100 mg/kg furosemide had no significant effect, 100 and 150 mg/kg ETA significantly reduced the CR of the eyes, and the time course of reduction in CR was quite similar to that in AEP. It is concluded that the function of the utricle is inhibited by the reduction of the endolymphatic potential.

Original languageEnglish
Pages (from-to)1325-1331
Number of pages7
JournalPractica Oto-Rhino-Laryngologica
Volume79
Issue number8
DOIs
Publication statusPublished - 1986 Jan 1

Keywords

  • counter-rolling
  • endolymphatic potential
  • loop diuretics

ASJC Scopus subject areas

  • Otorhinolaryngology

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