Effect of long-term, low-dose macrolide therapy on paranasal sinus aeration in chronic sinusitis patients

H. Suzuki, A. Shimomura, K. Ikeda, T. Oshima, T. Takasaka

Research output: Contribution to journalArticlepeer-review


The effect of a long-term and low-dose macrolide administration on chronic sinusitis patients was quantitatively evaluated by measuring the improvement of paranasal sinus aeration in computed tomography (CT) images. Ten patients with non-allergic chronic sinusitis were orally given 150 mg roxithromycin per day without other treatments for 4 to 11 months. They underwent CT scan of the paranasal sinuses before and after the treatment. Then, the proportion of aerated areas within the sinus (% aeration) was calculated using public domain NIH image program. Percent aeration significantly increased in the maxillary sinus, ethmoid sinus, sphenoid sinus and frontal sinus after the treatment by 29.4, 34.5 37.6 and 45.4% respectively. This result objectively and quantitatively demonstrates the clinical effectiveness of long-term and low-dose macrolide therapy on chronic sinusitis patients. In addition, percent aeration is thought to be an objective and useful parameter, which surpasses nasal symptom/objective finding scores or paranasal sinus X-rays in the evaluation of the severity of sinusitis.

Original languageEnglish
Pages (from-to)75-77
Number of pages3
JournalOto-Rhino-Laryngology Tokyo
Issue numberSUPPL. 2
Publication statusPublished - 1997
Externally publishedYes


  • Aeration
  • Chronic sinusitis
  • Long-term and low-dose administration
  • Macrolide antibiotics
  • Roxithromycin

ASJC Scopus subject areas

  • Otorhinolaryngology


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