Effect of long-term interferon-α administration on the mouse retina

Tohru Abe, Ako Nakajima, Makoto Ishikawa, Naoki Satoh, Shozo Sakuragi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

We studied the pathogenesis of interferon (IFN) retinopathy by long- term administration of IFN-α to mice that were naive, mice with diabetes, and mice with urethane-induced retinopathy. The dosage per weight and duration of IFN-α corresponded to those used to treat chronic hepatitis C. Administration of IFN-α promoted occlusion of the retinal vascular bed in mice with urethane-induced retinopathy but did not affect the retinas of naive or diabetic mice. These results suggest that an unhealthy retina is a prerequisite to the development of occlusion of retinal vessels with IFN-α.

Original languageEnglish
Pages (from-to)787-791
Number of pages5
JournalFolia Ophthalmologica Japonica
Volume47
Issue number7
Publication statusPublished - 1996
Externally publishedYes

Keywords

  • Interferon-α
  • Mouse
  • Retina
  • Urethane

ASJC Scopus subject areas

  • Ophthalmology

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