Abstract
We studied the pathogenesis of interferon (IFN) retinopathy by long- term administration of IFN-α to mice that were naive, mice with diabetes, and mice with urethane-induced retinopathy. The dosage per weight and duration of IFN-α corresponded to those used to treat chronic hepatitis C. Administration of IFN-α promoted occlusion of the retinal vascular bed in mice with urethane-induced retinopathy but did not affect the retinas of naive or diabetic mice. These results suggest that an unhealthy retina is a prerequisite to the development of occlusion of retinal vessels with IFN-α.
Original language | English |
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Pages (from-to) | 787-791 |
Number of pages | 5 |
Journal | Folia Ophthalmologica Japonica |
Volume | 47 |
Issue number | 7 |
Publication status | Published - 1996 |
Externally published | Yes |
Keywords
- Interferon-α
- Mouse
- Retina
- Urethane
ASJC Scopus subject areas
- Ophthalmology