Effect of local extension sites on survival in locally advanced maxillary sinus cancer

Satoshi Kano, Ryuichi Hayashi, Akihiro Homma, Kazuto Matsuura, Kengo Kato, Kazuyoshi Kawabata, Nobuya Monden, Yasuhisa Hasegawa, Tetsuro Onitsuka, Yasushi Fujimoto, Shigemichi Iwae, Kenji Okami, Takashi Matsuzuka, Kunitoshi Yoshino, Masato Fujii

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


Background We analyzed the effects of local extension sites on survival in patients with locally advanced maxillary sinus cancer. Methods The criteria for inclusion in this study were as follows: (1) previously untreated maxillary sinus cancer; (2) squamous cell carcinoma; (3) T4 disease; and (4) curative-intent treatment. The data for 118 patients were obtained from 28 institutions across Japan and analyzed for overall survival and local control rates by local extension site. Results Sites with a poor prognosis included the cribriform plate, dura, nasopharynx, middle cranial fossa, and cranial nerves other than V2. There was a significant correlation among these sites, except for the cranial nerves. Additionally, the hard palate was the only site that correlated with nodal involvement and showed a poor treatment outcome. Conclusion Even in cases presenting with similar T4 maxillary sinus cancer, treatment should be performed in consideration of the local extension site.

Original languageEnglish
Pages (from-to)1567-1572
Number of pages6
JournalHead and Neck
Issue number11
Publication statusPublished - 2014 Nov 1
Externally publishedYes


  • hard palate
  • local extension site
  • maxillary sinus cancer
  • radiation and intra-arterial cisplatin (RADPLAT)
  • total maxillectomy

ASJC Scopus subject areas

  • Otorhinolaryngology


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