Effect of leftventricular assistance for transient myocardial ischemia and recovery period

Y. Kakinuma, T. Yambe, T. Sonobe, S. Naganuma, H. Akiho, K. Idutsu, S. Kobayashi, S. Nanka, S. Nitta, N. Uchida, T. Fukuju, M. Miura, K. Tabayashi, M. Yoshizawa

Research output: Contribution to journalArticle

Abstract

In order to analyze the effect of left ventricular assist (LV-assist) on the stunned myocardium, acute animal experiments using 4 adult goats were carried out using the model of transient ischemia occluding the left anterior descending coronary artery for 3 minites. In this study, the end-systolic point (ESP) and the end-diastolic point (EDP) were calculated using pressure- volume curve (P-V curve) during transient ischemia and the recovery period, with and without LV-assist. In all parameters of ESP and EDP, LV-assist decreased the recovery time from transient myocardial ischemia. These results suggest that the decrease in pre-load and after-load with LV-assist contributes to the early recovery from stunned myocardium.

Original languageEnglish
Pages (from-to)18-24
Number of pages7
JournalJapanese Journal of Artificial Organs
Volume25
Issue number1
Publication statusPublished - 1996 May 14

Keywords

  • P-V curve
  • end-diastolic point
  • end-systolic point
  • left ventricular assist
  • transient ischemia

ASJC Scopus subject areas

  • Biophysics

Fingerprint Dive into the research topics of 'Effect of leftventricular assistance for transient myocardial ischemia and recovery period'. Together they form a unique fingerprint.

  • Cite this

    Kakinuma, Y., Yambe, T., Sonobe, T., Naganuma, S., Akiho, H., Idutsu, K., Kobayashi, S., Nanka, S., Nitta, S., Uchida, N., Fukuju, T., Miura, M., Tabayashi, K., & Yoshizawa, M. (1996). Effect of leftventricular assistance for transient myocardial ischemia and recovery period. Japanese Journal of Artificial Organs, 25(1), 18-24.