TY - JOUR
T1 - Effect of left ventricular assistance on sympathetic tone
AU - Yambe, T.
AU - Nitta, S.
AU - Katahira, Y.
AU - Sonobe, T.
AU - Tanaka, M.
AU - Miura, M.
AU - Satoh, N.
AU - Mohri, H.
AU - Yoshizawa, M.
AU - Takeda, H.
PY - 1990/1/1
Y1 - 1990/1/1
N2 - To determine the effect of left ventricular assist device (LVAD) pumping on sympathetic tone, renal sympathetic nerve activity (RSNA) was detected in acute animal experiments. Our TH-7B pneumatically driven, sac-type ventricular assist device was used in 7 adult mongrel dogs. RSNA was detected by the use of bipolar electrodes attached to the left renal sympathetic nerve. RSNA was amplified and integrated by use of an R-C integrator circuit. The area of the integrated nerve discharge per unit time was calculated in the computer system and expressed as RSNA per unit time. During LVAD pumping, RSNA decreased with increase in blood pressure, with an increase in pulmonary artery flow, and with a decrease in left atrial pressure. These data suggest that LVAD has an effect on the sympathetic nervous system which is mediated by the aortic and cardiopulmonary baroreflex system.
AB - To determine the effect of left ventricular assist device (LVAD) pumping on sympathetic tone, renal sympathetic nerve activity (RSNA) was detected in acute animal experiments. Our TH-7B pneumatically driven, sac-type ventricular assist device was used in 7 adult mongrel dogs. RSNA was detected by the use of bipolar electrodes attached to the left renal sympathetic nerve. RSNA was amplified and integrated by use of an R-C integrator circuit. The area of the integrated nerve discharge per unit time was calculated in the computer system and expressed as RSNA per unit time. During LVAD pumping, RSNA decreased with increase in blood pressure, with an increase in pulmonary artery flow, and with a decrease in left atrial pressure. These data suggest that LVAD has an effect on the sympathetic nervous system which is mediated by the aortic and cardiopulmonary baroreflex system.
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U2 - 10.1177/039139889001301009
DO - 10.1177/039139889001301009
M3 - Article
C2 - 2254045
AN - SCOPUS:0025052225
VL - 13
SP - 681
EP - 686
JO - Life Support Systems
JF - Life Support Systems
SN - 0391-3988
IS - 10
ER -