Effect of left ventricular assist on oxygen consumption in recovery period after transient myocardial ischemia

Y. Kakinuma, S. Nitta, T. Yambe, T. Sonobe, S. Naganuma, H. Akiho, K. Idutsu, S. Kobayashi, S. Nanka, M. Tanaka, T. Fukuju, M. Miura, N. Sato, H. Mouri, S. Koide, H. Takeda, T. Kasai, M. Yoshizawa

Research output: Contribution to journalArticlepeer-review

Abstract

To analyze the effect of left ventricular assist (LV-assist) on the stunned myocardium, acute animal experiments using 4 adult goats with LV-assist were carried out using the model of transient ischemia ligating the left anterior descending coronary artery. In this study, the pressure-volume area (PVA) according with oxygen-consumption and the external cardiac work (EW) were calculated using pressure-volume loop (P-V loop), with and without LV-assist. EW during LV-assist significantly decreased, compared with EW without LV-assist. However PVA did not significantly change with and without LV-assist. These results suggested that the decrease in EW contributed to the early recovery from stunned myocardium.

Original languageEnglish
Pages (from-to)904-910
Number of pages7
JournalJapanese Journal of Artificial Organs
Volume23
Issue number3
Publication statusPublished - 1994 Jan 1

Keywords

  • external cardiac work
  • left ventricular assist
  • pressure-volume area
  • pressure-volume loop
  • transient ischemia

ASJC Scopus subject areas

  • Biophysics

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