TY - JOUR
T1 - Effect of L-NG-Nitro-Arginine, Inhibitor of Nitric Oxide Synthesis, on Autoregulation of Renal Blood Flow in Dogs
AU - Kiyomoto, Hideyasu
AU - Matsuo, Hirohide
AU - Tamaki, Toshiaki
AU - Aki, Yasuharu
AU - Hong, He
AU - Iwao, Hiroshi
AU - Abe, Youichi
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1992/1
Y1 - 1992/1
N2 - The present experiments were designed to evaluate the importance of nitric oxide in the regulation of renal hemodynamics and the autoregulation of renal blood flow (RBF) in anesthetized dogs. RBF was measured by an electromagnetic flowmeter, and renal arterial pressure (RAP) was varied by an adjustable aortic clamp. The RAP-RBF relations were examined during the intrarenal infusion of saline or agents. The intrarenal infusion of L-NG-nitro-arginine (l-NNA, 40 μg/kg-min) at normal RAP decreased RBF and urine flow (UF), while the infusion of L-arginine-HCI (1 mg/kgmin) increased RBF and UF. Both agents did not affect the glomerular filtration rate and mean arterial pressure. The autoregulation of RBF was impaired during the l-NNA infusion. The L-arginine infusion did not affect autoregula-tory efficiency. When l-NNA (40 μg/kg-min) and L-arginine were infused simultaneously into the renal artery, the autoregulation of RBF was maintained. However, a higher dose of l-NNA (200 μg/kg-min) impaired the autoregulation of RBF. These results suggest that the basal production and/or the release of nitric oxide contributes to the regulation of renal hemodynamics and urine formation. During the reduction of RAP, nitric oxide may play an important role in the autoregulation of RBF.
AB - The present experiments were designed to evaluate the importance of nitric oxide in the regulation of renal hemodynamics and the autoregulation of renal blood flow (RBF) in anesthetized dogs. RBF was measured by an electromagnetic flowmeter, and renal arterial pressure (RAP) was varied by an adjustable aortic clamp. The RAP-RBF relations were examined during the intrarenal infusion of saline or agents. The intrarenal infusion of L-NG-nitro-arginine (l-NNA, 40 μg/kg-min) at normal RAP decreased RBF and urine flow (UF), while the infusion of L-arginine-HCI (1 mg/kgmin) increased RBF and UF. Both agents did not affect the glomerular filtration rate and mean arterial pressure. The autoregulation of RBF was impaired during the l-NNA infusion. The L-arginine infusion did not affect autoregula-tory efficiency. When l-NNA (40 μg/kg-min) and L-arginine were infused simultaneously into the renal artery, the autoregulation of RBF was maintained. However, a higher dose of l-NNA (200 μg/kg-min) impaired the autoregulation of RBF. These results suggest that the basal production and/or the release of nitric oxide contributes to the regulation of renal hemodynamics and urine formation. During the reduction of RAP, nitric oxide may play an important role in the autoregulation of RBF.
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U2 - 10.1254/jjp.58.147
DO - 10.1254/jjp.58.147
M3 - Article
C2 - 1507520
AN - SCOPUS:0026611931
VL - 58
SP - 147
EP - 155
JO - Japanese Journal of Pharmacology
JF - Japanese Journal of Pharmacology
SN - 0021-5198
IS - 2
ER -