TY - JOUR
T1 - Effect of Kaempferia parviflora extract and its polymethoxyflavonoid components on testosterone production in mouse testis-derived tumour cells
AU - Horigome, Satoru
AU - Maeda, Misato
AU - Ho, Hsin Jung
AU - Shirakawa, Hitoshi
AU - Komai, Michio
N1 - Publisher Copyright:
© 2016 Elsevier Ltd
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016/10/1
Y1 - 2016/10/1
N2 - Low testosterone is associated with late-onset hypogonadism, age-related disease, type 2 diabetes, and cardiovascular disease. In this study, we investigated the effects of Kaempferia parviflora extract and two of its components, 5,7-dimethoxyflavone and 5-hydroxy-3,7,3′,4′-tetramethoxyflavone, on testosterone production in mouse testis-derived tumour cells I-10. K. parviflora fractions containing 5,7-dimethoxyflavone elicited testosterone production in these cells, as did nobiletin, a polymethoxyflavonoid found in citrus species, but not K. parviflora, which was used as a comparative control. Furthermore, we found that these compounds enhanced testosterone production via cyclic AMP (cAMP)/cAMP response element binding protein signalling. In particular, the compounds inhibited activation of phosphodiesterase and thereby increased production of cAMP. These findings support the possibility that K. parviflora extract, 5,7-dimethoxyflavone, and nobiletin may mitigate age-related disease and hypogonadism by enhancing testosterone production.
AB - Low testosterone is associated with late-onset hypogonadism, age-related disease, type 2 diabetes, and cardiovascular disease. In this study, we investigated the effects of Kaempferia parviflora extract and two of its components, 5,7-dimethoxyflavone and 5-hydroxy-3,7,3′,4′-tetramethoxyflavone, on testosterone production in mouse testis-derived tumour cells I-10. K. parviflora fractions containing 5,7-dimethoxyflavone elicited testosterone production in these cells, as did nobiletin, a polymethoxyflavonoid found in citrus species, but not K. parviflora, which was used as a comparative control. Furthermore, we found that these compounds enhanced testosterone production via cyclic AMP (cAMP)/cAMP response element binding protein signalling. In particular, the compounds inhibited activation of phosphodiesterase and thereby increased production of cAMP. These findings support the possibility that K. parviflora extract, 5,7-dimethoxyflavone, and nobiletin may mitigate age-related disease and hypogonadism by enhancing testosterone production.
KW - Kaempferia parviflora
KW - Polymethoxyflavonoid
KW - Testis-derived tumour cells
KW - Testosterone production
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U2 - 10.1016/j.jff.2016.08.008
DO - 10.1016/j.jff.2016.08.008
M3 - Article
AN - SCOPUS:84983466523
VL - 26
SP - 529
EP - 538
JO - Journal of Functional Foods
JF - Journal of Functional Foods
SN - 1756-4646
ER -