Effect of intravenously infused eicosapentaenoic acid on the leukotriene generation in patients with active Crohn's disease

A. Ikehata, N. Hiwatashi, Y. Kinouchi, H. Yamazaki, Y. Kumagai, K. Ito, Y. Kayaba, T. Toyota

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Ten patients with active Crohn's disease who have been managed with parenteral-nutrition therapy were administered a lipid emulsion either with [containing 0.6 g eicosapentaenoic acid (EPA)] or without fish oil for 2 wk. We isolated polymorphonuclear leukocytes (PMNLs) from the patients before and after this treatment and measured the amounts of leukotriene B4 (LTB4) and leukotriene B5 (LTB5) generated by activated PMNLs by reversed-phase HPLC. The LTB5 generation in active Crohn's disease before this treatment was significantly lower than in healthy control subjects. The amount of LTB5 and the LTB5-LTB4 ratio increased significantly after fish-oil supplementation. The difference with LTB4 was not statistically significant. We have shown that daily intravenous administration of 0.6 g EPA influenced the generation of leukotrienes in active Crohn's disease even after short-term treatment. Further investigations are necessary to clarify the correlation between EPA and clinical improvement in Crohn's disease.

Original languageEnglish
Pages (from-to)938-942
Number of pages5
JournalAmerican Journal of Clinical Nutrition
Volume56
Issue number5
DOIs
Publication statusPublished - 1992 Jan 1

Keywords

  • Crohn's disease
  • Fish oil
  • eicosapentaenoic acid
  • leukotriene B
  • leukotriene B

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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