Effect of intratympanic application of efinaconazole 10 % solution in the guinea pig

Kazuya Arakawa, Kazuhiro Nomura, Hidetoshi Oshima, Yohei Honkura, Ryoukichi Ikeda, Hiroshi Hidaka, Tetsuaki Kawase, Yukio Katori

Research output: Contribution to journalArticlepeer-review

Abstract

Efinaconazole 10 % solution is a new triazole antifungal agent developed for the topical treatment of fungal infections of the nails. The current study examined the effect of intratympanic application of efinaconazole 10 % solution in the guinea pig ear. Sixteen male Hartley guinea pigs (weight 501–620 g) were divided into 3 groups to be treated with efinaconazole 10 % solution, gentamicin (50 mg/mL), or saline solution. Topical solutions of 0.2 mL were applied through a small hole made at the tympanic bulla once daily for 7 consecutive days. Post-intervention auditory brainstem responses were obtained 7 days after the last treatment. The extent of middle ear damage and hair cell loss was investigated. The efinaconazole- and gentamicin-treated groups showed severe deterioration in auditory brainstem response threshold. Middle ear examination revealed extensive changes in the efinaconazole-treated group and medium changes in the gentamicin-treated group. Hair cells were preserved in the efinaconazole- and saline-treated groups, but severe damage was seen in the gentamicin group. In conclusion, efinaconazole 10 % solution applied intratympanically to the guinea pig middle ear caused significant middle ear inflammation and hearing impairment.

Original languageEnglish
Pages (from-to)1137-1142
Number of pages6
JournalEuropean Archives of Oto-Rhino-Laryngology
Volume273
Issue number5
DOIs
Publication statusPublished - 2016 May 1

Keywords

  • Aspergillus
  • Candida
  • Fungus
  • Hearing loss
  • Otomycosis

ASJC Scopus subject areas

  • Otorhinolaryngology

Fingerprint

Dive into the research topics of 'Effect of intratympanic application of efinaconazole 10 % solution in the guinea pig'. Together they form a unique fingerprint.

Cite this