Effect of intracoronary thrombectomy on 30-day mortality in non-diabetic patients with acute hyperglycemia after acute myocardial infarction

Masaya Usami, Yasuhiko Sakata, Daisaku Nakatani, Masahiko Shimizu, Shinichiro Suna, Sen Matsumoto, Masatsugu Hori, Hiroshi Sato

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Background: There is limited evidence about useful therapeutic interventions for patients with acute hyperglycemia (AH) after acute myocardial infarction (AMI). Methods: We studied 2433 consecutive non-diabetic AMI patients who underwent percutaneous coronary intervention (PCI) within 24 h after the onset. Patients were divided into two groups according to the presence or absence of AH (admission serum glucose level ≥11.1 mmol/l). We assessed the association between intracoronary thrombectomy and the clinical outcome in AMI patients with AH. Results: Patients with AH had more risk factors than those without AH. The 30-day mortality rate of patients with AH was significantly higher than that of those without (11.7% vs 1.7%, p < 0.001). Among patients with AH, the 30-day mortality rate was significantly lower for those with intracoronary thrombectomy than those without it (4.9% vs 17.2%, p = 0.004). Among patients without AH, however, the 30-day mortality rate was similar between those with and without intracoronary thrombectomy (1.5% vs 1.9%, p = NS). Multivariate analysis showed that intracoronary thrombectomy was associated with an improved 30-day mortality rate for patients with AH (hazard ratio: HR 0.184, 95% CI 0.057-0.598, p = 0.005). Conclusions: In AMI patients with AH, intracoronary thrombectomy prior to PCI might improve the 30-day mortality rate.

Original languageEnglish
Pages (from-to)429-436
Number of pages8
JournalJournal of cardiology
Volume53
Issue number3
DOIs
Publication statusPublished - 2009 Jun
Externally publishedYes

Keywords

  • Acute hyperglycemia
  • Acute myocardial infarction
  • Thrombectomy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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