Effect of hypocalcemia on divalent cation-activated ATPase and Ca2+ uptake in microsomes of rat kidney cortex

T. Dan, M. Gemba

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1 Citation (Scopus)


Effects of hypocalcemia on Ca2+ metabolism of microsomes from rat kidney cortex were studied. Microsomal activities of Ca2+-ATPase, Mg2+-ATPase and (Na++K+)-ATPase increased 30-33 days after Ca2+ restriction or low Ca2+ vitamin D depletion, but alkaline phosphatase activity decreased. Calcium repletion in diet and injection of 1α-hydroxycholecalciferol or 1,25-dihydroxycholecalciferol were partially successful in returning Ca2+-ATPase and Mg2+-ATPase activity, but not (Na++K+)-ATPase and alkaline phosphatase activity, to normal. Correlations between serum Ca2+ level and both ATPase activities were significant. ATP-dependent Ca2+ uptake of microsomes was not affected by hypocalcemia and vitamin D metabolites.

Original languageEnglish
Pages (from-to)318-326
Number of pages9
JournalRenal Physiology
Issue number6
Publication statusPublished - 1979 Jan 1

ASJC Scopus subject areas

  • Physiology
  • Nephrology


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