Abstract
Effects of hypocalcemia on Ca2+ metabolism of microsomes from rat kidney cortex were studied. Microsomal activities of Ca2+-ATPase, Mg2+-ATPase and (Na++K+)-ATPase increased 30-33 days after Ca2+ restriction or low Ca2+ vitamin D depletion, but alkaline phosphatase activity decreased. Calcium repletion in diet and injection of 1α-hydroxycholecalciferol or 1,25-dihydroxycholecalciferol were partially successful in returning Ca2+-ATPase and Mg2+-ATPase activity, but not (Na++K+)-ATPase and alkaline phosphatase activity, to normal. Correlations between serum Ca2+ level and both ATPase activities were significant. ATP-dependent Ca2+ uptake of microsomes was not affected by hypocalcemia and vitamin D metabolites.
Original language | English |
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Pages (from-to) | 318-326 |
Number of pages | 9 |
Journal | Renal Physiology |
Volume | 2 |
Issue number | 6 |
Publication status | Published - 1979 |
Externally published | Yes |
ASJC Scopus subject areas
- Physiology
- Nephrology