Effect of Helicobacter pylori Infection on Gastric Acid Secretion and Meal-Stimulated Serum Gastrin in Children

Seiichi Kato, Kyoko Ozawa, Tomoyuki Koike, Hitoshi Sekine, Shuichi Ohara, Takanori Minoura, Kazuie Iinuma

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

Background. Comparative studies of gastric acid secretion in children related to Helicobacter pylori infection are lacking. The purpose of this study was to compare acid secretion and meal-stimulated gastrin in relation to H. pylori infection among pediatric patients. Materials and Methods. Thirty-six children aged 10-17 years (17 with H. pylori infection) undergoing diagnostic endoscopy participated in the study. Diagnoses included gastritis only (n = 23), duodenal ulcer (n = 5) and normal histology (n = 8). Gastric acid output was studied using the endoscopic gastric secretion test before and 2-3 months after H. pylori eradication. Meal-stimulated serum gastrin response was assessed before and 12 months after eradication. Results. H. pylori gastritis was typically antrum-predominant. Acid secretion was greater in H. pylori-positive patients with duodenal ulcer than in gastritis-only patients or controls [mean ± standard error (SE): 6.56 ± 1.4, 3.11 ± 0.4 and 2.65 ± 0.2 mEq/10 minutes, respectively; p < .001]. Stimulated acid secretion was higher in H. pylori-positive boys than girls (5.0 ± 0.8 vs. 2.51 ± 0.4 mEq/10 minutes, respectively; p < .05). Stimulated acid secretion pre- and post-H. pylori eradication was similar (5.47 ± 0.8 vs. 4.67 ± 0.9 mEq/ 10 minutes, respectively; p = .21). Increased basal and meal-stimulated gastrin release reversed following H. pylori eradication (e.g. basal from 134 to 46 pg/ml, p < .001 and peak from 544 to 133 pg/ml, p < .05). Conclusions. H. pylori infection in children is associated with a marked but reversible increase in meal-stimulated serum gastrin release. Gastric acid hypersecretion in duodenal ulcer remains after H. pylori eradication, suggesting that the host factor plays a critical role in outcome of the infection.

Original languageEnglish
Pages (from-to)100-105
Number of pages6
JournalHelicobacter
Volume9
Issue number2
DOIs
Publication statusPublished - 2004 Apr 30

Keywords

  • Child
  • Duodenal ulcer
  • Gastric acid
  • Gastrin
  • Gastritis
  • Helicobacter pylori

ASJC Scopus subject areas

  • Gastroenterology
  • Infectious Diseases

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