Effect of halothane and enflurane on hepatic blood flow and oxygen consumption in dogs

Eiji Masaki, Nobuhiko Yasuda, Yasumasa Tanifuji, Jun Kimura, Kenichi Kobayashi

Research output: Contribution to journalArticlepeer-review


We investigated the relative effects of 0.5, 1.0, 1.5, 2.0 MAC halothane and enflurane, and concurrent noxious stimulus on hepatic blood flow and oxygen consumption in 14 mongrel dogs randomly divided into groups of seven each. Hepatic arterial and portal venous blood flow (HABF and PVBF, respectively) were measured continuously using ultrasonic transit time flow meter. Mean arterial blood pressure (MAP), cardiac index (CI), hepatic oxygen supply, and hepatic oxygen consumption (HV02) were measured. Halothane significantly deceased HABF, but not PVBF in a dose dependent manner. Enflurane did not affect HABF and PVBF significantly. MAP and CI decreased in both groups, with halothane producing more marked decreases than enflurane. HV02, did not change with enflurane, but did with halothane, producing significant differences, with halothane being greater at 1.5, 2.0 MAC. A noxious stimulus only caused minor change in blood flow. The results suggest that liver blood flow and oxygen consumption are affected differently by halothane and enflurane and that halothane has a stronger tendency to cause an imbalance between liver oxygen supply and consumption than dose enflurane.

Original languageEnglish
Pages (from-to)118-122
Number of pages5
JournalJournal of Anesthesia
Issue number2
Publication statusPublished - 1989 Sep


  • enflurane
  • halothane
  • hepatic blood flow
  • hepatic oxygen consumption

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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